Advate, Baxter (1 vial contains nominally 250 IU, 500 IU, 1000 IU, 1500 IU, 2000 IU, or 3000 IU human coagulation factor VIII (octocog alfa) recombinantly obtained in Chinese hamster ovary cells. After reconstitution, each ml of solution for injection contains respectively: 50 IU, 100 IU, 200 IU, 300 IU, 400 IU or 600 IU octocog alfa, specific activity is about 4000 - 10,000 IU / mg protein, the preparation contains sodium: 0.45 mmol sodium (10 mg) per vial. )
BeneFIX, Wyeth Europe (1 vial contains 250 IU, 500 IU, 1000 IU or 2000 IU of nonacog alfa. After reconstitution, 1 ml contains 50 IU, 100 IU, 200 IU, or 400 IU nonakogal alpha respectively.)
Beriate, CSL Behring
Berinin P, CSL Behring (1 vial contains 300 IU, 600 IU, or 1200 IU, respectively, of human IX blood clotting factor.)
Beriplast® P, Centeon Pharma (The Beriplast P 0.5 ml kit contains 4 vials with various substances: vial 1 - human fibrinogen concentrate: 37.5-57.5 mg fibrinogen and factor XII - 20-40 IU, vial 2 - aprotinin - 500 Km. (kininogen activator units) vial 3 - thrombin - 200-300 IU, vial 4 - calcium chloride 2.5 ml - 14.7 mg (40 mmol / l) Beriplast P 1.0 ml kit contains: vial 1 - concentrate human fibrinogen: 65-115 mg fibrinogen and factor XII - 40-80 IU, vial 2 - aprotinin 1000 KI (kininogen activator units), vial 3 - thrombin - 400-600 IU, vial 4 - calcium chloride 2.5 ml - 14.7 mg (40 mmol / l) Beriplast P 3.0 ml contains: vial 1 - concentrate of human fibrinogen: 195-345 mg of fibrinogen and factor XII - 120-240 IU, vial 2 - aprotinin 3000 Kj. m. (kininogen activator units) vial 3 - thrombin 1200-1800 IU, vial 4 - calcium chloride 7.5 ml - 44.1 mg (40 mmol / l).
Beriplex P / N, CSL Behring (1 vial of Beriplex P / N 250 contains nominally: 200-480 IU of factor II, 100-250 IU of factor VII, 200-310 IU of factor IX, 220-600 IU of factor X and 150-450 IU of protein C, 120-380 IU S. 1 vials Beriplex P / N 500 contains nominally: 400-960 IU of factor II, 200-500 IU of factor VII, 400-620 IU of factor IX, 440-1200 IU of factor X and 300-900 IU of protein C, 240- 760 IU protein S. The specific activity of factor IX is 2.5 IU / mg total protein The medicine contains sodium (up to 343 mg / 100 ml).)
Feiba Tim 4 Immuno, Baxter (The activity of the preparation is always indicated on the packaging: 1 unit corresponds to the amount of activated prothrombin complex, which if the factor VIII inhibitor or deficient factor is present, will correct the partial thromboplastin time to 35 seconds.)
Haemoctin, Biotest Pharma (1 vial contains nominally 250 IU, 500 IU, or 1000 IU of coagulation factor VIII made from human plasma, specific activity is about 100 IU / mg protein, 1 vial contains up to 32.2 mg sodium (1.4 mmol).)
Immunate Baxter, Baxter Polska (1 vial contains 250 IU of human coagulation factor VIII and 125 IU von Willebrand factor (after reconstitution in 5 mL of the solvent contains 50 IU and 25 IU respectively) 1 vial contains 500 IU of human coagulation factor VIII and 250 IU von Willebrand factor (after reconstitution in 5 ml of solvent contains 100 IU and 50 IU respectively) 1 vial contains 1000 IU of human coagulation factor VIII and 500 IU von Willebrand factor (after dissolving in 10 mL of solvent it contains 100 IU and 50 IU respectively).)
Immunate ™ Stim Plus, Baxter (1 vial contains a concentrate of human factor VIII with a procoagulant activity of 250 IU, 500 IU or 1000 IU.)
Kogenate Bayer, Bayer Pharma (1 vial contains nominally 250 IU, 500 IU, 1000 IU, 2000 IU, or 3000 IU of human coagulation factor VIII (octocog alfa) recombinantly obtained in kidney cells of young hamsters. The specific activity is approximately 4000 IU / mg protein.)
NovoEight, Novo Nordisk
NovoSeven, Novo Nordisk (1 vial contains 1 mg, 2 mg, 5 mg or 8 mg eptacog alfa (activated) After reconstitution with the solvent, the preparation contains 1 mg / ml eptacog alfa (activated) and 10 mg / ml sucrose.)
NovoThirteen, Novo Nordisk (1 vial (3 ml) contains 2500 IU of cathalidecacac (recombinant coagulation factor XIII) (rDNA) After reconstitution, 1 ml of solution contains 833 IU of recombinant XIII coagulation factor, specific activity is approximately 165 IU / mg protein.)
Octanate, Octapharma (1 vial contains nominally 250 IU, 500 IU.or 1000 IU human coagulation factor VIII. The medicine contains sodium (less than 1 mmol (23 mg) / vial of 250 IU, up to 1.75 mmol (40 mg) / vial of 500 IU and up to 1.75 mmol (40 mg) / vial of 1,000 IU).)
Octanine, Octapharma (1 vial contains 500 IU or 1000 IU of human IX blood clotting factor, specific activity is about 100 IU factor IX per mg protein. The medicine contains sodium (up to 3 mmol (69 mg) / vial of 500 IU, up to 6 mmol (138 mg) / vial 1000 IU).)
Octaplex, Octapharma (1 vial contains human prothrombin complex - nominally: 280-760 IU of human II blood coagulation factor, 180-480 IU of human VII blood coagulation factor, 500 IU of human IX blood coagulation factor, 360-600 IU of human X of coagulation factor and 260- 620 IU protein C and 240-640 IU S protein. Specific drug activity is ≥ 0.6 IU / mg protein, expressed as factor IX activity. The drug contains sodium (75-125 mg / vial) and heparin (100-250 IU) / vial, corresponding to 0.2-0.5 IU / I of factor IX).)
Prothromplex Total NF, Baxter Polska (1 vial contains a set of plasma prothrombin coagulation group with activity of 600 IU. It contains: Factor IX, Factor II, Factor VII, Factor X and about 250 IU of heparin and 15-30 IU of antithrombin III as stabilizers.)
Recombinate, Baxter Polska (1 vial contains nominally 250 IU, 500 IU, or 1000 IU octocog alfa recombinant coagulation factor VIII, obtained by genetic engineering in Chinese hamster ovary cells. After reconstitution, 1 ml solution for injection contains 25 IU, 50 IU or 100, respectively jm oktokogu alfa. The specific activity is about 4000 - 8000 IU / mg protein, the preparation contains 1.5 mmol sodium per dose.)
ReFacto AF, Wyeth Europa (1 vial contains 250 IU, 500 IU, 1000 IU, or 2000 IU moroctocog alfa.) After reconstitution, 1 ml of solution contains approximately 62.5 IU, 125 IU, 250 IU, or 500 IU moroctocog alfa. After reconstitution, 1 vial contains 1, 23 mmol (29 mg) of sodium.)
Riastap, CSL Behring (1 vial contains 1 g of human fibrinogen.) The reconstituted 50 ml of water for injections contains approximately 20 mg / ml human fibrinogen and contains up to 164 mg of sodium (7.1 mmol) per vial.)
TachoSil, Takeda (1 cm2 The therapeutic sponge contains: 5.5 mg of human fibrinogen and 2 IU human thrombin.)
Tisseel Lyo, Baxter Polska (Component 1 - Adhesive protein solution (adhesive protein concentrate, lyophilized, to be dissolved in an aprotinin solution): human fibrinogen (as a thrombotic protein) - 91 mg / ml; aprotinin (synthetic) - 3000 KIU / ml; polysorbate 80 (excipient) - 0.6-1.9 mg / ml.Ingredient 2- Thrombin solution (freeze-dried thrombin, to be dissolved in a calcium chloride solution): human thrombin - 500 IU / ml; calcium chloride - 40 μmol / ml. The drug contains human factor XIII, co-purified with human fibrinogen, in amounts of 0.6-5 IU / ml.)
Trasylol, Bayer (1 bottle of 50 ml contains a concentrated solution of aprotinin with an activity of 277.8 units of Ph. Eur., Corresponding to 500,000 KIU (kallikrein inactivation units))
Vitacon, Polfa Warsaw (1 ml of solution contains 10 mg of fitomenadion The drug contains macrogolglycerol ricinoleate.)
Vitacon, Polfa Warsaw (1 coated tablet contains 10 mg of fitomenadion.) The drug contains lactose, sucrose and quinoline yellow lake.)
Wilate, Octapharma (1 vial contains 450 IU of human coagulation factor VIII and 400 IU of von Willebrand factor 1 vial contains 900 IU of human coagulation factor VIII and 800 U.m. von Willebrand factor.)
(C)
