Fibrates increase good cholesterol, lower the level of fat in the blood
AIMS OF PHARMACOLOGICAL TREATMENT
Blood analysis revealed that you have too high total cholesterol and LDL cholesterol.
Are you wondering - is too high a general level of cholesterol and its LDL fraction harmful to your health? We will try to answer your questions.
The correct concentration of total cholesterol in the blood
The correct level of total cholesterol in the bloodthat is, it does not threaten your health - it can not exceed 200 mg / dl (5.2 mmol / l), and preferably it does not exceed 180 mg / dl.
A particular risk to the arteries is excess cholesterol of the fraction commonly referred to as 'bad' cholesterol (LDL). LDL cholesterol is usually about 3/4 of the total amount of cholesterol in the blood. LDL cholesterol readily oxidizes under the influence of free radicals and sticks to the inside of the arteries, initiating the growth of atherosclerotic plaque.
It is assumed that the physiologically safe concentration of low-density cholesterol (LDL) should not be higher than 130 mg / dl.
Paradoxically, however, the protection against atherosclerosis is not low, but possibly high blood levels of the cholesterol fraction called "good" cholesterol - called HDL in short. HDL cholesterol "cleanses" the arteries from the excess of atherogenic LDL cholesterol. It catches its excess from the blood and transports it to the liver, where LDL cholesterol becomes beneficial for the body with bile biotextile, steroid hormones, etc. Thanks to the activity of good HDL cholesterol, the risk of diseases and cardiovascular complications, including infarction and stroke, is reduced. .
It is assumed that the level of good cholesterol should be at least 35 mg / dl in men and 40 mg / dl in women.
In addition, blood levels of fats known as triglycerides (triglycerides) are important.
The concentration is considered to be the correct leveltriglyceridesnot exceeding 180 mg / dl.
Once we know what the test results mean - they must not be underestimated! Excess cholesterol, although it does not hurt, is a "silent killer"! It accelerates atherosclerosis, resulting in vasoconstriction or even clogging. This leads to ischemic heart disease, heart attack and stroke, i.e. very serious diseases threatening to disability or even death.
So what should you do to avoid cardiovascular diseases?
When in the blood test, for example, we find too high a level of general and too low HDL cholesterol, it is worth setting two key goals: lowering the total amount of cholesterol and raising the level of good HDL cholesterol. The double target more effectively reduces the risk of atherosclerosis and its cardiovascular complications. This applies especially to people who are already ill or at risk of coronary heart disease, which is emphasized, for example, by the recommendation of an expert team published in the prestigious journal "The American Journal of Cardiology" in July, bison. It recommends: "raising the level of HDL cholesterol to equal or greater than 40 mg% (1mmol / l) both for people with cardiovascular disorders and for people at high risk - especially for people with type 2 diabetes and those with syndrome metabolism - abdominal obesity combined with prolonged excess insulin in the blood. " Another important recommendation of the aforementioned group of experts is the recommendation: - lifestyle changes - quitting (or avoiding) smoking, getting rid of overweight, diet modification (avoiding fats), regular physical exercise, which together should lead to an appropriate increase in HDL cholesterol.
The use of non-pharmacological methods is not always helpful
The flatness of blood (hyperlipidemia) may be stronger. If prophylaxis turns out to be ineffective, medicines that regulate lipid metabolism should be used. The most commonly used group of drugs in hyperlipidemias are fibrates.
FIBRATES LOWER THE BLOOD LEVEL IN THE BLOOD - AND AROUND THE LEVEL OF A GOOD CHOLESTER
Fibrates are a very commonly used group of drugs in the treatment of atherosclerosis. They reduce total cholesterol by 20 - 25%. And most importantly, they reduce the level of bad LDL cholesterol by 20% (on average!) And above the level of good HDL cholesterol by 10 - 15%! They also lower the elevated triglyceride concentration by 40-60%. It was found that some fibrates, in some patients can raise the level of "good" HDL cholesterol by as much as 90%! Beneficial changes also take place inside the "bad" LDL cholesterol; lipoprotein molecules from this group become larger and heavier.
Increasing the level of good HDL cholesterol while reducing the amount of LDL and triglycerides prevents atherosclerosis and its dangerous consequences - heart attack, stroke.
Recommended by doctors when there is too much lipid in the blood ...
Physicians usually use fibrates in the case of high levels of triglycerides, but also in cases of concurrent elevation of cholesterol and triglycerides and at a low level of "good" HDL cholesterol. Fibrates have a particularly beneficial effect on patients with diabetes with accompanying lipid disorders.
Fibrates inhibit atherosclerosis, reduce attacks of coronary pain
Numerous experimental and clinical studies have shown that fibrates inhibit atherosclerotic processes in vessels, reduce the incidence of coronary pain, the incidence of heart attacks and ischemic strokes.
Antioxidant effect
Drugs from this group also have anti-inflammatory, antioxidant effects (similar to vitamins C and E) and prevent excessive blood clotting. They improve the physiological efficiency of the inner membrane of blood vessels most at risk of atherosclerosis. Some studies also show an improvement in carbohydrate metabolism, including in patients with diabetes.
Fibrates are well tolerated.
During their reception, only occasionally abdominal pain, diarrhea, vomiting and skin rash may occur. Serious complications are extremely rare (they may occur in patients with renal insufficiency and with simultaneous use of statin drugs).
Fibrates are a group of well-known medicines because they have been used in the world by many hundred thousand patients for almost thirty years.
These drugs are cheaper than many other medicines of similar use.
Their constantly re-discovered and documented by current research, high healing efficacy results in a true renaissance of their application.
It should be added that these are drugs for which a medical prescription is necessary. The dose is also determined by the doctor. Often, after reducing the plasma lipids, the dose is reduced. In any case, taking fibrates with other medicines, the indications for their use should be discussed with your doctor.
