Seen the causes of psoriasis in: genetic background and gene inheritance, bacterial, viral and fungal infections, undesirable effects of certain drugs, diets (high calorie products and abundant animal fats, alcohol), mechanical injuries, stress, etc. The more disease factors - the more likely initiation of the disease and increased symptoms of psoriasis.
The influence of genetic conditions
Genetic factors exert a large, although not entirely known, effect on the development of psoriasis. Some researchers recognize psoriasis as a disease inherited in a "dominant" manner, from the so-called incomplete gene penetration, which means that not all people who inherit the "psoriatic gene / disease" will show up! Others point to the so-called multifactorial inheritance, taking into account both genetic and environmental influences on the appearance of the disease.
Genes decide?
Some researchers believe that the probability of developing psoriasis in a child if one of the parents is ill is around 25%; in the case of a disease in both parents, the probability increases to about 70%. The study of twins speaks for an important role of hereditary factors. Simultaneous occurrence of psoriasis in identical twins is significantly more frequent than in diabetic twins. However, the fact that the compliance rate in identical twins varies from 40 to 65% indicates the important role of environmental factors in causing disease.
Based on genetic tests, psoriasis is divided into two types:
- Type I (juvenile) - usually manifests before 40 years of age, more often occurs in the family, has a more severe course and is characterized by the presence of CW6 HLA antigen in about 80% of patients.
- Type II - (adults) - discloses after 40 years of age The course of the disease is milder, rarely occurs in the family. The presence of HLA B44 and Cw4 antigens is statistically more frequent in these cases.
The risk of developing psoriasis for people with B17 antigen expression is high and independent of age.
What causes sowing of psoriatic eruptions?
1. Acute infections (bacterial, viral) - they should always be treated intensively
2. Chronic infections (in sinuses, dentition, gallbladder, appendages)
3. Some medicines (antibiotics, e.g. tetracyclines, antimalarial drugs, B-adrenergic blocking agents, lithium salts)
4. Stress
5. Mechanical irritation of the skin (scratching, removing scales from psoriatic efflorescence by brushing)
6. Improper use of steroid preparations (generally used initially cause rapid resolution of skin lesions, but after discontinuation of these medications, rapid relapses with severe course)
What usually provokes the first appearance of the disease?
The risk of disease symptoms is sometimes associated with the start of treatment with beta blockers, lithium salts or disturbances in the calcium-phosphate economy. Especially often, the first seeding of psoriatic lesions in life is preceded by an acute infection of the upper respiratory tract (angina, bronchitis, viral diseases). There was also a higher incidence of psoriasis in AIDS patients and after vaccination.
How long have we been sick?
Psoriasis is a chronic, long-lasting disease, practically incurable. It is characterized by relapses, which means that it is accompanied by periods of exacerbation and remission. Treatment only leads to regression of disease symptoms (remission), but it does not allow its permanent elimination. Significant hopes have recently been associated with immomodulation methods.
ed.
Literature:
1. Practical dermatology; dermatologists: Małgorzata Opalińska, Katarzyna Prystupa, Wadim Stąpór, Wyd. Lek. PZWL 1997.
2.Practical tips for diagnosing and treating psoriasis Dr. Adam Borzęcki from the Department
Dermatological and Military Hospital in Lublin Head of the Department; Medycyna Rodzinna - 9 (1/2000)
3. Contemporary views on etiopathogenesis and psoriasis treatment - Aneta Szczerkowska Dobosz -adiunkt Dyrektor
and the Department of Dermatological and Venereal Diseases in Gdańsk - • http://www.sluzbazdrowia.com.pl
