Table. 5 mg. Primary hypertension.Table. 5 mg and 10 mg. Edema caused by congestive heart failure, pulmonary edema, edema of hepatic origin, edema of renal origin.
Composition:
1 tabl contains 5 mg or 10 mg of torasemide.
Action:
A drug from the group of loop diuretics. At low doses, the pharmacodynamic profile of the drug is similar to thiazide diuretics, taking into account the severity and duration of diuresis. At higher doses, torasemide causes rapid diuresis depending on the dose used and is characterized by high efficiency. After oral administration, the torasemide is absorbed quickly and almost completely, reaching a maximum blood concentration after 1-2 hours. Over 99% of the drug is bound to plasma proteins. Torasemide is metabolised to three metabolites by oxidation and hydroxylation of the aromatic ring. About 80% of the administered dose is excreted unchanged and as metabolites as a result of tubular secretion. T0,5 is 3-4 hours. In case of renal failure T0,5 it does not change.
Contraindications:
Hypersensitivity to torasemide, sulfonylurea derivatives or other components of the preparation. Renal impairment with anuria. Hepatic coma and pre-coma. Hypotension. Heart arythmia. Pregnancy and breastfeeding. Co-administration with aminoglycosides or cephalosporins.
Precautions:
Before starting treatment, the water and electrolyte balance should be restored and the cause of the dysfunction should be resolved. Patients with hepatic impairment should be under special control because of the risk of increasing the amount of torasemide in the blood. Careful monitoring of patients prone to increased uric acid in the blood and gout is recommended. Carbohydrate metabolism should be monitored in patients with latent or overt diabetes.
Pregnancy and lactation:
The drug is contraindicated during pregnancy and breastfeeding.
Side effects:
Common: exacerbation of symptoms of metabolic acidosis, muscle cramps, increased uric acid, Glucose, triglycerides and cholesterol in the blood, hypokalemia (especially with low-potassium diet, accompanied by vomiting, diarrhea, use of large amounts of laxatives, and in the case of dysfunction liver), decreased appetite, stomach pain, nausea, vomiting, diarrhea, constipation, increased levels of liver enzymes in the blood (eg γ-GT), pain and dizziness, fatigue, weakness. Uncommon: elevation of urea and creatinine in the blood (in patients with impaired urine outflow, eg in the case of prostatic hypertrophy, this can lead to urinary retention and damage to the bladder), dry mouth, paresthesia. Very rare: thrombotic complications due to blood thickening, disorientation, cardiac circulatory disorders and o.u.n. (including heart and brain ischemia, which may lead to cardiac arrhythmias, angina pectoris, heart attacks or fainting), pancreatitis, hypersensitivity reactions (eg pruritus, rash, hypersensitivity to light), severe skin reactions, decreased the number of erythrocytes, leukocytes and platelets, visual disturbances, tinnitus, hearing loss. Depending on the dose and length of treatment, symptoms of loss of electrolytes and fluids may appear, in particular oligemia, hypokalemia and / or hyponatremia.
Dosage:
Orally. Adults.Primary hypertension: usually 2.5 mg once a day; if necessary, the dose can be increased to 5 mg once a day. Studies suggest that doses greater than 5 mg per day do not lead to further lowering of blood pressure. The maximum therapeutic effect is achieved after about 12 weeks of treatment.edema: usually 5 mg once a day. If necessary, the dose may be gradually increased to 20 mg once a day. In individual, exceptional cases, a dose of 40 mg per day was used. There is no clinical experience with the use of the preparation in children.Usage. The tablets should be taken in the morning with a small amount of liquid, regardless of the meal. The tablets are divisible.
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