Treatment of symptoms of chronic venous insufficiency of the lower limbs (varicose veins): pain, cramps, tingling, swelling, skin changes on the background of blood stagnation.
The preparation reduces the permeability of capillaries, increases their strength, preventing the formation of exudates and improving microcirculation. It increases the tension of the vein wall, preventing blood stasis and the formation of blood clots. Increases the synthesis of collagen. It has a beneficial effect on hemodynamic blood parameters, reducing plasma viscosity and increasing its flow through peripheral tissues. It inhibits the aggregation of thrombocytes. The sealing effect of the vessel within the lymphatic system causes an increase in the outflow of lymph and reduction of edema, which leads to relief of pain and feeling of heaviness in the limbs. The action starts within 1-2 h after administration. It binds to 20-25% of plasma proteins. It is excreted in 50% with urine and 50% with faeces, mainly unchanged. T0,5 is about 5 hours.
Contraindications:
Hypersensitivity to the active substance or to any of the excipients.
Precautions:
In patients with severe renal impairment, the dose should be reduced. Use with caution in patients with chronic recurrent catarrh of the stomach and in gastric and duodenal ulcer. The patient should be advised to consult a doctor if the following symptoms occur: fever, sore throat, infection in the mouth or other signs of infection (risk of agranulocytosis). The preparation contains lactose - patients with rare, congenital lactose intolerance, Lapp lactase deficiency or malabsorption of glucose-galactose should not use the drug.
Pregnancy and lactation:
The use of the drug during pregnancy is possible only if the anticipated benefits of therapy outweigh the potential risk of harmful effects on the fetus. The use of the drug in the first trimester of pregnancy is contraindicated. The drug penetrates to breast milk in a minimal degree - do not use during breastfeeding or discontinue treatment.
Side effects:
Rare: nausea, diarrhea, dizziness, drug-induced fever. Very rare: agranulocytosis, itchy rash with erythema.
Dosage:
Orally. Adults: 2 tabl. 1-2 times a day. The duration of treatment ranges from a few weeks to several months. The tablets should be taken during meals.
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