Treatment of symptoms of venous and lymphatic insufficiency, especially in the lower limbs (feeling of heaviness in the legs, pain, night spasms, varicose veins). Treatment of symptoms of the severity of ailments associated with varicose veins.
Composition:
One capsule contains 200 mg or 300 mg Troxerutin (o-β-hydroxyethyl-rutosides).
Action:
Ruthenium derivatives (o-β-hydroxyethylrututosides) have a protective effect on the walls of the capillaries, reduce the permeability of small vessels, which contributes to the reduction of edema. They increase the tension and elasticity of blood vessels, counteracting their cracking. In high doses, they increase the plasticity of the red blood cell membranes and counteract the aggregation of platelets, thereby improving blood flow in small vessels. Troxerutin administered orally is absorbed mainly within the small intestine. The maximum concentration in the blood occurs after 2 to 3 hours. It is reversibly associated with plasma proteins. It is metabolised to glucuronides, aglycones and arylacetic acids. T0,5 is 10-18 h. It is excreted in the urine and in the stool.
Contraindications:
Hypersensitivity to the components of the preparation. The drug should not be used in patients with rare hereditary galactose intolerance, lactase deficiency (Lapp type) or malabsorption of glucose-galactose.
Precautions:
Do not use the product in children or in patients with edema around the ankles caused by heart, liver or kidney disease.
Pregnancy and lactation:
There are no data on possible adverse effects on the fetus and breastfed newborn. The drug is not recommended during the first three months of pregnancy.
Side effects:
Rare: skin rash, pruritus, urticaria, flatulence, diarrhea, abdominal pain, indigestion, discomfort in the stomach. Very rare: hypersensitivity to light, alopecia, nausea, vomiting, headache and dizziness, fatigue, anaphylactic shock, anaphylactoid reaction, hypersensitivity, flushing, fatigue, fatigue, joint pain. If these side effects occur, it is recommended to reduce the dose by half or periodically discontinued.
Dosage:
Oral: 2 capsules of 200 mg 3 times a day or 1 capsule of 300 mg 4 times a day for 2 to 4 weeks. For maintenance treatment, usually lasting 3 to 4 weeks or for relapses: 2 capsules 200 mg 2 times a day or 1 capsule 300 mg three times a day.Way of giving. Take this medicine during a meal.
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