Long-lasting pupil dilation, diagnostic eye tests, refraction tests in young children. Treatment of iritis and iridocyclitis to prevent iris-lenticular adhesions.
Composition:
1 ml of solution contains 10 mg of atropine sulphate. Drops contain benzalkonium chloride.
Action:
The cholinolytic drug competitively inhibits muscarinic peripheral as well as central receptors. Atropine sulphate has a relaxant effect on the pupil sphincter and the ciliary body muscle, which widens the pupil and paralyzes the eye's accommodation. In addition, it has a relaxant effect on the smooth muscle of the gastrointestinal tract, urinary tract, gall bladder and bronchi. It has an inhibitory effect on the secretion of most glands, including sweat glands (except for milk). It affects heart function by inhibiting the transmission of the vagus nerve. By modifying the activity of the sinoatrial node and atrio-ventricular node, it speeds up heart function. Atropine sulphate is absorbed into the systemic circulation after administration to the conjunctival sac. It is metabolised in the liver, excreted in small amounts in the form of metabolites and in unchanged form. Hydroxyethyl cellulose contained in the preparation gives the drops the appropriate viscosity and extends the time of their operation.
Contraindications:
Hypersensitivity to the preparation ingredients and to cholinolytic drugs. Primary glaucoma with a tendency to close the angle. Glaucoma with a narrow angle.
Precautions:
Use with caution in infants, young children, pregnant women, and elderly patients. The extension of the iris can accelerate glaucoma in patients over 60 years of age (due to angle closure). Due to the content of benzalkonium chloride, soft contact lenses should not be worn during the application period. Before using the product, contact lenses should be removed and inserted after at least 30 minutes after administration. Benzalkonium chloride may cause eye irritation and discoloration of contact lenses.
Pregnancy and lactation:
During pregnancy, use only if the anticipated benefits to the mother outweigh the potential risk to the fetus. Use with caution when breastfeeding.
Side effects:
The following may occur: disturbances in vision and accommodation, increased intraocular pressure (at narrow angle), conjunctivitis, pruritus, eyelid edema, tearing, hypersensitivity to light. The general adverse reactions of atropine sulphate can occur during treatment.
Dosage:
In the case of ophthalmologic tests, the dosage is set individually. Eye refraction test: children under 3 years of age use a 0.25% solution of atropine sulphate - 1 drop into the conjunctival sac twice daily for 5 days; in children aged 3 to 6, a 0.5% solution is used - 1 drop into the conjunctival sac twice daily for 5 days; in children over 6 years, 1% solution is used - 1 drop into the conjunctival sac 2 times a day for 3 days. In all age groups, an additional dose can be given immediately before the test. Therapeutically: 1 drop into the conjunctival sac up to 2 times a day. After instilling the preparation, the internal angle of the eyelid must be pressed for approx. 1 min.
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