Index of drugs

Corneal ulcers and superficial ocular infections (eyes) and appendages of the eye caused by sensitive bacterial strains that have been shown to respond to ciprofloxacin.

1 ml of solution or 1 g of eye Ointment contains 3 mg of Ciprofloxacin as hydrochloride.

Antibiotic from the group of quinolones. It exerts bactericidal action by inhibiting DNA gyrase. It works on Gram-negative bacteria (incl.Pseudomonas aeruginosa, Acinetobacter spp., Hemophilus influenzae, Moraxella spp.) and Gram-positive bacteria:Staphylococcus spp., Staphylococcus aureus (along with methicillin-sensitive and methicillin-resistant strains),S. epidermidis, other coagulose negativeStaphylococcus spp. (includingS. haemolyticus andS. hominis), Corynebacyerium spp., Streptococcus pneumoniae, Streptococcus groupviridans. In conditionsin vitro ciprofloxacin has the lowest inhibitory concentration (MIC) against the majority (90%) of the following eye pathogens: Gram-positive aerobic micro-organisms:Bacillus sp.; Gram-negative oxygen microorganisms:Acinetobacter calcoaceticus, Enterobacter aerogenes, Escherichia coli, Haemophilus parainfluenzae, Klebsiella pneumoniae, Neisseria gonorrhoeae, Proteus mirabilis, Proteus vulgaris, Serratia marcescens. Sensitive are:Peptococcus spp., Peptostreptococcus spp., Propionibacterium acnes andClostridium perfringens. Insensitive: some strainsBurkholderia cepacia andStenotrophomonas maltophilia, some anaerobic bacteria, especially Bacteroides fragilis. Ciprofloxacin penetrates the tissues of the eye very well, reaching high concentrations in the tear film, cornea and anterior chamber. When given locally to the eye, it penetrates the bloodstream only to a small extent.

Hypersensitivity to ciprofloxacin or to any of the excipients. Hypersensitivity to other quinolones.

The use of the preparation should be discontinued immediately after the occurrence of skin rash or any other signs of hypersensitivity. During treatment, excessive exposure to sunlight should be avoided; if phototoxicity occurs, the preparation should be discontinued. Prolonged use of ciprofloxacin may cause excessive growth of non-susceptible organisms, including fungi - if superinfection occurs, appropriate treatment should be initiated. The preparation has not been studied in patients with hepatic or renal impairment. The benzalkonium chloride contained in the preparation may cause irritation and discoloration of soft contact lenses. Contact lenses should be removed before instillation and wait 15 minutes after instillation before re-insertion. In the period of eye infection, contact lenses are not recommended.

During pregnancy, use only if the anticipated benefits to the mother outweigh the potential risk to the fetus. It is not known if ciprofloxacin administered locally passes into breast milk. Take special care while using the drug during breastfeeding.

They are usually mild and transient.Drops. Common: eye discomfort, white sludge formation in patients with corneal ulceration who frequently used the drug (the precipitate appears from 24 h to 7 days from the start of treatment, does not affect the clinical course of the ulcer or the result in the field of vision), body sensation stranger, creation of scabs / crystals on the edges of the eyelids, conjunctival hyperaemia, pruritus, taste disturbances. Rare: corneal discoloration, caratopathy, keratitis, allergic reactions, eyelid edema, tearing, photophobia, corneal infiltration, visual impairment, dermatitis, nausea.Ointment. Common: eye discomfort, white sludge formation in patients with corneal ulceration who have used the drug frequently (the precipitate appears from 24 h to 7 days from the start of treatment, has no effect on the clinical course of the ulcer or the visual effect). Uncommon: blurred vision, congestion, pruritus, worsening of visual acuity, pain, tearing, photophobia, dry eye syndrome, dysgeusia.

Adults, youth and children over 1 year.Drops. Corneal ulcer: on the first day of treatment - for the first 6 hours - 2 drops into the conjunctival sac of the affected eye (eyes) every 15 minutes, and for the remainder of the day - 2 drops every 30 minutes. On the second day: 2 drops every 1 hour. From the 3rd to the 14th day of treatment - 2 drops every 4 hours. The drug should be used both during the day and at night. Corneal ulcers may require treatment for more than 14 days. Superficial infections of the eye and its appendages: usually 1-2 drops into the conjunctival sac of the affected eye (eyes) 4 times a day. In the case of serious infections, the dosage in the first 2 days can be 1-2 drops every 2 hours during wakefulness. The length of treatment is usually 7-14 days. After instillation, gentle closing of the eyelids and compression of the nasal-lacrimal duct are recommended.Ointment. Corneal ulcers: in the first 2 days of treatment, an ointment with a debt is inserted into the conjunctival sac of the infected eye (eyes). 1.25 cm every 1-2 hours (around the clock). For the Next 12 days, the ointment is applied every 4 hours (around the clock). Corneal ulcers may require treatment for more than 14 days. Superficial infections of the eye and its appendages: ointment roller with debt. 1.25 cm is introduced into the conjunctival sac or into the lower eyelid of the infected eye (eyes) 3 times a day for 2 days; then the drug is used twice daily for the next 5 days. The length of treatment is usually 7-14 days. Eye ointment may be used before going to sleep, in combination with eye drops during the day. It is recommended to gently close the eyelid after applying the medicine.
If the patient uses more than one eye medicine, each of the medicines should be given at least 10-15 minutes apart; the medicine in the form of an ointment should be used at the end.