Acute conjunctivitis in the course of seasonal and perennial allergic eye inflammation. Conjunctivitis caused by the use of contact lenses, exposure to the sun, cigarette smoke, contact with water in the swimming pool, etc.
Composition:
1 ml of solution contains 5 mg of antazoline sulphate and 0.25 mg of naphazoline nitrate. The preparation contains benzalkonium chloride.
Action:
A combination drug that contains an antihistamine - antazoline and α-adrenomimetic - nafazoline. Antazoline is an H receptor antagonist1 1st generation. It inhibits allergic symptoms, especially those associated with the release of histamine, such as dilation and increased capillary permeability. Naphazoline applied topically shrinks conjunctival blood vessels and eliminates symptoms associated with inflammation. The combination of two substances with different mechanisms of action leads to the removal of local inflammatory symptoms of the conjunctiva such as pruritus, pain, burning, tearing, etc., especially if they are allergic. The full local effect of nafazoline appears in 5 min. after topical application. The effect lasts for 6-8 h. Nafazoline can be absorbed from mucous membranes, causing general symptoms, although this effect is unlikely in adults after conjunctival sac. General reactions mainly occur in the elderly and young children. The occurrence of general antazoline activity is very unlikely.
Contraindications:
Hypersensitivity to the active substances or to any of the excipients. Glaucoma with a narrow angle. Hypersensitivity to adrenomimetic agents.
Precautions:
In patients with chronic conjunctivitis, the drug should be used for a short time and only in the case of exacerbation of symptoms. The use of the drug for more than 5 days or more than every 3 hours is not recommended because of the risk of rebound, secondary to the severity of edema and increased secretion, as well as the possibility of permanent changes in the epithelium. The preparation contains benzalkonium chloride, which may cause eye irritation. Avoid contact with soft contact lenses. Before taking the medicine, remove the contact lenses and wait at least 15 minutes before putting them on again. Benzalkonium chloride changes the color of contact lenses.
Pregnancy and lactation:
The preparation can be used during pregnancy only if the benefits for the mother outweigh the potential risk to the fetus. There are no data on the penetration of active ingredients in breast milk. The preparation should be used with caution when breastfeeding.
Side effects:
There are usually transient conjunctival symptoms: burning, pruritus, blurred vision and conjunctival hyperemia. Rarely are drowsiness, drowsiness, increased blood pressure, headaches and dizziness, nausea, eye pain. Lack of improvement or intensification of local changes are indications for discontinuation of the drug.
Dosage:
Adults and children over 6 years: 1-2 drops into the conjunctival sac, if necessary, the dose can be repeated after 4-6 h. The drug should not be used for more than 3-5 days. After instillation, gently close the eye, do not blink and do not open the eye for about 2 minutes for the medicine to be absorbed. After instillation, gently press the tip of the closed eyelid with a fingertip for 1-2 min. This can prevent the drops from flowing down the tear ducts to the nose and the occurrence of systemic side effects.
(C)
