Index of drugs

Conditions of elevated intraocular pressure. Glaucoma with an open angle.

1 ml of solution contains 5 mg of betaxolol in the form of hydrochloride. Drops contain benzalkonium chloride.

A selective β-blocker for topical use, acts antagonistically to β receptors₁, there is no membrane stabilizing activity or intrinsic sympathomimetic activity. The drug reduces intraocular pressure by reducing the production of aqueous humor. In addition, it increases the flow of blood in the eye. Betaksolol, due to its high lipophilicity, penetrates the cornea well and reaches high concentrations in the eye structures.

Hypersensitivity to the active substance or to any of the excipients. Respiratory dysfunction syndrome, including current or history of severe bronchial asthma, severe chronic obstructive pulmonary disease. Sinus bradycardia, sick sinus syndrome, sinoatrial block, atrioventricular block of second or third degree uncontrolled pacemaker, symptomatic heart failure, cardiogenic shock.

In patients with cardiovascular disease (eg ischemic heart disease, Prinzmetal's angina and heart failure) and in patients with hypotension treated with β-blockers, a risk assessment should be performed and treatment with another active substance should be considered. Patients with cardiovascular disease should be observed to exacerbate the symptoms of the disease and side effects. Use with caution in patients with heart block I; with severe peripheral circulation disorders (e.g., severe Raynaud's disease or Raynaud's syndrome); with or with a history of mild to moderate bronchial asthma or with mild or moderate chronic obstructive pulmonary disease (cases of respiratory disorders, including death in asthmatic patients, as a result of bronchial spasm following the administration of some β-blockers to the eye); in patients with diabetes (unstable or hypoglycaemic), because the medicine may mask the symptoms of hypoglycaemia; in people with suspected thyrotoxicosis; in patients with corneal diseases. In patients with atopy or severe anaphylactic reactions to various allergens in the course of β-blocker therapy, a stronger hypersensitivity reaction to allergens may occur, and the usual dose of adrenaline may be ineffective. The anesthetist should be informed about the use of betaxolol prior to surgical anesthesia, as the drug may change the patient's response to anesthetic drugs. In patients with closed-angle glaucoma requiring immediate treatment, the drug can be used to lower intraocular pressure in combination with a pupil constricting agent. A case of choroidal detachment has been described during therapy that inhibits the production of aqueous humor (eg Timolol, acetazolamide) after filtration. It is recommended to observe patients taking concomitant oral β-blockers and betaxolol in eye drops (risk of adding up to intraocular pressure and systemic side effects).
The use of two β-blockers to the eyes is not recommended. Due to the content of benzalkonium chloride, the preparation may cause eye irritation and change the color of soft contact lenses. Do not use the medicine when using soft contact lenses. Before dropping the medicine, you must remove the contact lenses and wait at least 15 minutes before re-inserting.

During pregnancy, use only if absolutely necessary. If the medicine is used before delivery, the newborn should be closely monitored during the first days of life. The drug is excreted in breast milk in amounts that do not cause adverse reactions in the newborn.

Common: discomfort. Uncommon: tearing.Rare: reduced corneal sensitivity, redness of the eye, itching, spot corneal discoloration, keratitis, anisocoria, hypersensitivity to light, insomnia, depression, headache, bradycardia, dyspnea, asthma, hair loss. In addition, systemic allergic reactions may occur (including angioneurotic edema, urticaria, local and generalized rash, pruritus, anaphylactic reaction); hypoglycaemia, nightmares, memory loss, syncope, cerebral ischemia, exacerbation of signs and symptoms of myasthenia gravis, dizziness, paresthesia, chest pain, palpitations, edema, arrhythmia, congestive heart failure, atrioventricular block , cardiac arrest, heart failure, hypotension, Raynaud's phenomenon, cold hands and feet, bronchospasm (mainly in patients with pre-existing bronchospasm), cough, taste disturbances, nausea, indigestion, diarrhea, dry mouth, pains abdomen, vomiting, psoriatic rash or exacerbation of psoriasis, skin rash, muscle pain, sexual dysfunction, decreased libido, weakness, fatigue, symptoms of eye irritation (burning, stinging, itching, tearing, redness), blepharitis, keratitis, impaired vision and choroidal detachment after filtration procedures, var increasing corneal sensitivity, dry eyes, corneal erosion, eyelid drooping, double vision.

Adults (also elderly patients). The conjunctival: 1 drop to the affected eye (eyes) 2 times a day.Special groups of patients. Use in children is not recommended.Way of giving. It is recommended, after instillation of each drop, to spot the lacrimal sac at the medial angle of the eye (compressing the tear point) for about 1 min to reduce the potential systemic absorption.