Index of drugs

Infections caused by susceptible microorganisms: respiratory tract infections, exacerbation of chronic bronchitis, pneumonia (caused by microorganisms of the genusMycoplasma pneumoniae, Rikettsia spp. andChlamydia spp.). Infections of the genitourinary system caused by microorganisms of the genusChlamydia, Ureaplasma urealyticum, acute prostatitis, uncomplicated cases of gonorrhea - especially with simultaneous infection caused byChlamydia; female genital infection, syphilis (Treponema pallidum) - if you are allergic to penicillin; urinary tract infection (only with confirmed sensitivity to the antibiotic). Gastrointestinal infections eg cholera (Vibrio cholerae), infections caused byYersinia pestis, Campylobacter fetus andShigella sp. with confirmed antibiotic sensitivity, tropical sprue, Whipple's disease, traveler's diarrhea. Skin infections, e.g. severe forms of acne vulgaris (Acne vulgaris) and rosacea (Acne rosacea). Eye infections caused by microorganismsChlamydia trachomatis: intracranial conjunctivitis and trachoma. Lyme disease (Lyme disease) caused byBorrelia burgdoferiwhen chronic erythematous erythema and rare infections like brucellosis occur (Brucella spp.), ornithosis (Chlamydia psittaci), bartonellosis (Bartonella baciliformis), listeriosis (Listeria monocytogenes), riketsjoza (Rickettsia acari), malinica (Treponema pertenue), plague (Yersinia pestis), inguinal granuloma (Calymmatobacterium granulomatosis).

1 hard capsules contain 100 mg of Doxycycline in the form of a monohydrate.

Tetracycline antibiotic with a broad spectrum of antibacterial activity. It exerts a strong bacteriostatic effect due to inhibition of bacterial protein biosynthesis. Susceptible strains include: Gram-negative bacteria (inclNeisseria gonorrhoeae, Haemophilus influenzae, Brucella spp.), Gram-positive bacteria (Streptococcus haemolyticus (α andβ), Streptococcus pneumoniae, Staphylococcus aureus, Staphylococcus epidermidis, Propionibacterium acnes) and other microorganisms (Rikettsia spp., Chlamydia spp., Mycoplasma spp., Ureaplasma spp.). Medium-sensitive strains include: Gram-negative bacteria (Escherichia coli, Enterobacter spp., Bacteroides spp., Klebsiella spp., Salmonella spp. andShigella spp.), Gram-positive bacteria (Bacillus anthracis, Listeria monocytogenes). Usually resistant strains include:Enterococcus spp., Pseudomonas spp., Proteus spp., Serratia spp. andProvidencia spp.Doxycycline also acts on other microorganisms: Actinomyces spp., Leptospira, Nocardia spp., Treponema pallidum, T. pertenue, Clostridium perfringens, C. tetani, Fusobacterium fusiforme, Entamoeba spp., Balantidium coli and Plasmodium falciparum. Doxycycline is completely absorbed from the gastrointestinal tract and undergoes a first-pass effect. It binds plasma proteins in 80-90%. It penetrates well into tissues and body fluids with the exception of cerebrospinal fluid, in which its concentration is 10-20% of the concentration in the blood. Accumulates in the bones and teeth, especially high concentrations achieved in the liver and bile ducts. It is metabolized to a small extent. It is excreted in the unchanged urine (40%) and in the feces in the form of an inactive chelate (20-40%). T_0,5 in the blood after a single administration is 16-18 h, after repeated administration 22-23 h.

Hypersensitivity to Tetracycline or any component of the preparation. Severe hepatic failure. It is not recommended for use during pregnancy and breastfeeding, because it penetrates the placenta and into breast milk. Do not use the medicine before the end of the forming period, i.e. in the second half of pregnancy and in children under 12 years of age. As a result of the calcium-orthophosphate compounds deposition, permanent tooth discoloration, enamel damage or delay of skeletal development may occur.

Discontinuation of doxycycline should be considered if the patient has a blood clotting disorder.When using the antibiotic for a long time, check the blood and liver and kidney function regularly. During treatment with Doxycycline, the patient should avoid sunbathing or tanning, as allergic reactions may occur in areas exposed to UV radiation, including redness, edema, blistering, and less likely to delaminate and discolor the nails. As with other antibiotics, excessive growth of non-susceptible organisms may occur, including fungal infections. During the use of the drug may experience allergic reactions, including severe or life-threatening. If diarrhea occurs, it should be stated whether this is a symptom of pseudomembranous colitis. In light cases, it is enough to discontinue the drug, in the event of failure and in severe conditions, oral Metronidazole or Vancomycin is administered. Do not use drugs that inhibit peristalsis. Use with caution in patients with renal failure. Symptoms of mild intracranial pressure increase in adult patients have been described, as well as the bladder depressions in infants. The symptoms subsided completely after discontinuation of the drug. Patients who are allergic to any of the tetracycline medicines may also be allergic to doxycycline (so-called cross-allergy). Treatment with doxycycline should be discontinued if the patient has porphyria or myasthenia gravis. Doxycycline may reduce the effectiveness of oral contraceptives (it is advisable to use additional methods of contraception). The medicine should not be taken in a lying position or immediately before going to bed because inflammation or ulceration of the esophagus may occur.

It is allowed to use the preparation in pregnancy only when it is absolutely necessary to provide it to the mother. Tetracyclines have hepatotoxic effects in pregnant women, moreover, their administration in the second trimester of pregnancy leads to delayed fetal skeletal development, irreversible discoloration of teeth and damage to the enamel. It should not be used during breast-feeding.

Common: disorders of the development of teeth and bones, bone fragility, irreversible discoloration of teeth (especially in developing tissues, e.g. in children), muscle and joint pain. Uncommon: vestibular disorders (tinnitus and dizziness), abdominal pain, lack of appetite, nausea, vomiting, diarrhea, indigestion, photodermatosis, maculopapular rash and erythema. Rarely: haemolytic anemia, thrombocytopenia, neutropenia, eosinophilia, convex tendonitis in infants (caused by a mild increase in intracranial pressure), mild increase in intracranial pressure with irritation of the meninges and dilation of pupils in older children and adults, headache, difficulty swallowing, black tongue, stomatitis, anal pruritus, impaired liver function with transient elevation of liver enzymes, hepatitis, increased blood urea, worsening azotemia in people with renal failure, exfoliative dermatitis, urticaria, superinfection caused by resistant microorganisms (yeast infections , inflammation of the tongue, staphylococcal enteritis, pseudomembranous colitis - with excessive growthClostridium dificilleinflammation of the genital and anal area - with excessive growthCandidavaginitis and oral cavity). Very rare: porphyria, decreased prothrombin activity, transient tinnitus, dizziness, blurred vision, conduction defects, diplopia, colitis, pseudomembranous colitis (a condition requiring immediate interruption of treatment), hepatic failure with jaundice, symptoms of Fanconi syndrome - appearance of albumin, Glucose, amino acids in the urine, hypophosphatemia, hypokalemia, renal acidosis, toxic epidermal necrolysis, Stevens-Johnson syndrome, brown-black thyroid discoloration after long-term use (without thyroid dysfunction), hypersensitivity reactions (in including anaphylactic shock), hypotension, exacerbation of diffuse lupus erythematosus, serum sickness, peripheral edema, pericarditis, angioneurotic edema, anaphylaxis, dyspnoea, tachycardia, blood blows. The use of tetracyclines disturbs the results of glucose, protein, urobilinogen and catecholamines in the urine.

Orally. Adults about the month up to 70 kg and adolescents with mc. > 50 kg: usually 200 mg once on the first day, then daily 100 mg once a day; in severe infections of 200 mg throughout the course of treatment. Adults about the month > 70 kg: 200 mg daily. Children> 12 years and about <50 kg: on the first day 4 mg / kg, followed by 2 mg / kg on subsequent days. once a day. Acute menstrual discharge of ureters in men: 200 mg per day in 1-2 doses for 7 days. Acute epididymitis epididymitis: 100 mg twice daily for 10 days. Acute gonorrheal infection in women: 200 mg per day in 1-2 doses for at least 7 days. Primary and secondary syphilis (if you are allergic to penicillin): 300 mg / day (the drug can be administered once a day) for 15 days. Acne or acne acne: 100 mg daily for 2-4 weeks, then 50 mg for 2-3 weeks. The drug should be administered up to 3 days after the symptoms disappear. In infections caused by streptococci, the β-hemolytic drug should be used for at least 10 days to prevent rheumatic fever or glomerulonephritis. In patients with renal insufficiency, no dose adjustment is usually necessary. Capsules should be taken with a full glass of water; drinking with a small amount of water may facilitate inflammation or ulceration of the esophagus. Taking the medicine during meals may reduce the frequency of gastrointestinal side effects, while it does not affect the extent of absorption of the drug. Do not take doxycycline with milk products. Omitting one dose of doxycycline does not necessitate a change in taking subsequent doses.