Infections of the upper and lower respiratory tract - palatine tonsillitis, pharyngitis, otitis media, sinusitis, bronchitis, pneumonia, caused byHaemophilus influenzae, Klebsiella spp., Streptococcus pneumoniae, Mycoplasma pneumoniae, Chlamydia pneumoniae. Urinary tract infections - pyelonephritis, cystitis, urethritis, induced byChlamydia trachomatis, Ureaplasma urealyticum. Sexually transmitted diseases caused byChlamydia trachomatis, syphilis (Treponema pallidum), soft ulcer (Haemophilus ducreyi), inguinal ostomy (Calymmatobacterium granulomatis), gonorrhea (Neisseria gonorrhoeae). Soft tissue infections caused by susceptible strainsClostridium spp., Propionibacterium acnes. Gastrointestinal infections caused by enteropathogenic strainsEscherichia coli (traveler's diarrhea),Entamoeba histolytica, Shigella spp., Vibrio cholerae, Clostridium spp.Ophthalmic infections - Chronic conjunctivitis caused byChlamydia trachomatis (trachoma); it can be treated with Doxycycline alone or in combination with topical medications. Other infections - parrots (Chlamydia psittaci), brucellosis (Brucella spp.) in combination with streptomycin, plague (Yersinia pestis), tularemia (Francisella tularensis). In the prevention of malaria. Before commencing treatment with Doxycycline, susceptibility testing of isolated microbial infection should be performed. Treatment may be implemented before the susceptibility of the organism is obtained. After obtaining the result of the antibiogram, it may be necessary to change the drug accordingly. When deciding on treatment with the preparation, official guidelines for the use of antimicrobial agents should be taken into account.
Composition:
One capsule contains 100 mg of doxycycline in the form of hyclate.
Action:
Tetracycline antibiotic with bacteriostatic activity. Works, among others for Gram-negative bacteria (inclNeisseria gonorrhoeae, Campylobacter granulomatis, Haemophilus ducreyi, Brucella spp., Yersinia pestis), Gram-positive bacteria (high percentage of resistant strains) and other microorganisms, including atypical bacteria (incl.Chlamydia psittaci and Ch.trachomatis, Mycoplasma pneumoniae, Ureaplasma urealyticum), Borrelia recurrentis, Rikettsia spp., Treponema pallidum, Bacillus anthracis, Plasmodium falciparum. Doxycycline is quickly absorbed from the gastrointestinal tract; the dairy diet and ions of some metals slightly reduce absorption. Plasma protein binding is 80-90%. It penetrates very well into tissues and body fluids, achieving high concentrations, including in the prostate gland, uterus, ovaries, bladder, bile, bronchi, sinuses and lungs; it also crosses the placenta barrier and into breast milk. Poorly penetrates into the cerebrospinal fluid. Doxycycline is metabolised in the liver and excreted unchanged in the urine and in the form of metabolites in the faeces. T0,5 in the blood is 18-22 h.
Contraindications:
Hypersensitivity to doxycycline, other tetracyclines or any of the excipients of the preparation. Severe hepatic failure. Children under 12 years old; Pregnancy (especially the second half).
Precautions:
Use with caution in patients with hepatic impairment or other hepatotoxic medications. During the treatment, exposure to UV radiation (sun exposure, solarium) should be avoided due to the risk of photodermatitis.
Pregnancy and lactation:
Do not use during pregnancy and breast-feeding.
Side effects:
Pain and dizziness, sudden redness of the face, intracranial hypertension in adults and children (causing, among others, visual disturbances), tinnitus, mild and transient gastrointestinal disturbances (lack of appetite, nausea, vomiting, diarrhea, abdominal pain, inflammation of the tongue , difficulty in swallowing, ulceration of the esophagus, inflammation of the intestine, inflammatory changes of the anus), increased blood urea, allergic reactions (symptoms of serum sickness, angioneurotic edema, anaphylactic purpura, hypotension, dyspnoea, tachycardia,pericarditis, anaphylactic shock, skin rash, urticaria, pruritus, photosensitivity, exfoliative dermatitis, Stevens-Johnson syndrome, toxic necrotic epidermal separation), rare anemia, thrombocytopenia, leukopenia, granulocytosis, porphyria, brown-black discoloration of the thyroid gland, pain in joints and muscles, tooth development disorders, enamel discoloration, superinfection with resistant microorganisms (anal pruritus, stomatitis and tongue inflammation, genital inflammation, pseudomembranous colitis, staphylococcal enteritis), transient elevation of blood transaminases, rarely liver dysfunction , hepatitis, jaundice, pancreatitis.
Dosage:
Orally. Adults about the month up to 70 kg and adolescents over 12 years of age> 50 kg: first day: 200 mg in one dose or 100 mg every 12 hours, then 100 mg once a day. Adults about the month > 70 kg or severe infections: 200 mg once a day. In uncomplicated gonorrhea: 100 mg every 12 hours for at least 7 days; in sexually transmitted diseases caused byCh. trachomatis orUreaplasma urealyticum: 100 mg every 12 hours for 7-10 days; in primary and secondary cortex in patients allergic to penicillin: 200-300 mg per day in divided doses for 2 weeks. In the prevention of malaria: 100 mg per day, starting the treatment for 1-2 days before the journey in areas endangered by malaria and continuing its use during the stay and for 4 weeks after returning. The product should be taken at least 30 minutes before bedtime (you should not lie down immediately after the reception); it can also be used during a meal.
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