Imodium Multi-Action, McNeil Products / Johnson & Johnson
indications:
Treatment of acute diarrhea and symptoms that are often associated with it, such as abdominal pain, bloating, cramping and excess gas.
Composition:
1 tabl for chewing and chewing contains 2 mg of Loperamide hydrochloride and 125 mg of simethicone.
Action:
A drug that inhibits intestinal peristalsis. Loperamide binds to the opioid receptors in the intestinal wall. It reduces propulsive peristalsis, prolongs passage time through the intestines and increases the absorption of water and electrolytes. Increases the tension of the anal sphincter. It does not work centrally. It is easily absorbed from the intestine, but is almost completely captured by the liver, where it is metabolized, conjugated and excreted in the bile. T0,5 in the blood is about 9-14 h. Simethicone is a surfactant with anti-foaming properties; it relieves symptoms associated with diarrhea, especially such as bloating with wind blows, aching and abdominal cramps. Simethicone is not absorbed.
Contraindications:
Hypersensitivity to the components of the preparation. Children under 12 years. Acute bacterial dysentery with blood in the stool and running with high fever. A sharp projection of ulcerative enteritis. Inflammation of the small intestine and colon caused by pathogenic bacteria of the genusSalmonella, Shigella andCampylobacter. Pseudomembranous enteritis, associated with the administration of broad-spectrum antibiotics. Do not use in cases where avoidance of intestinal motility should be avoided because of the possible risk of serious complications, including intestinal obstruction and colonic distension. Treatment should be stopped immediately if constipation, abdominal distension or bowel obstruction occur.
Precautions:
Use with caution in patients with hepatic impairment due to reduced metabolism associated with the hepatic first pass; Patients with hepatic impairment should be carefully monitored for signs of toxicity from o.u.n. In patients with AIDS treated for diarrhea, treatment should be discontinued if the first signs of abdominal distension occur. Treatment should be discontinued if no improvement in the clinical condition of the patient occurs within 48 hours after administration. Due to the content of sucrose and sorbitol, the drug should not be used in patients with rare inherited disorders associated with fructose intolerance, malabsorption of glucose-galactose or sucrase-isomaltase deficiency.
Pregnancy and lactation:
The drug should not be used during pregnancy, especially in the first trimester, unless the benefit for the mother outweighs the potential risk to the fetus. Small amounts of loperamide may be found in human milk, therefore the use of the preparation during breastfeeding is not recommended.
Side effects:
Common: headaches, taste disorders; nausea. Uncommon: insomnia, dizziness, abdominal pain, abdominal pain, epigastric pain, vomiting, constipation, abdominal distension, indigestion, bloating, dry mouth, rash, weakness. Rarely: hypersensitivity reactions, anaphylactic reaction (including anaphylactic shock) and anaphylactoid reaction; loss of consciousness, dementia, decreased level of consciousness, hypertonia, incorrect coordination; miosis; intestinal obstruction (including paravenous ileus), dilation of the colon (including toxic dilation of the colon); bullous rash (including Stevens-Johnson syndrome, toxic epidermal necrolysis and erythema multiforme), angioneurotic edema, urticaria, pruritus; urinary retention, fatigue.
Dosage:
Orally. Adults and children from the age of 12: initially 2 tablets, then 1 tabl. after each loose stool. The maximum daily dose is 4 tablets. The preparation should not be used for more than 2 days.
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