Short-term treatment of cold or flu symptoms such as fever, headache, sore throat, myalgia and osteoarticular pain.
Composition:
1 tabl Effervescent contains 500 mg of Paracetamol and 300 mg of ascorbic acid. In addition, the preparation contains 15 mg aspartame, 167 mg sodium.
Action:
A preparation with analgesic and antipyretic effect. Paracetamol by inhibiting the activity of arachidonic acid cyclooxygenase inhibits the synthesis of prostaglandins in o.u.n., resulting in an increase in the pain threshold. The reduction in the concentration of prostaglandins in the hypothalamus causes antipyretic effects. Quickly and almost completely absorbed from the gastrointestinal tract. Cmaxin blood reaches after about 1 hour. T0,5 is 2-4 h. Painkiller duration is 4-6 h and antipyretic 6-8 h. Metabolized in the liver, excreted through the kidneys. Vitamin C exerts a stimulating effect on the body's immune processes. The maximum concentration in the blood reaches after 2-3 h.
Contraindications:
Hypersensitivity to the active substance or to any of the excipients. Congenital G-6-PD deficiency. Severe hepatic or renal failure. Urolithiasis. Viral hepatitis. Alcoholic disease. Phenylketonuria (the preparation contains aspartame). The use of MAO inhibitors and the period of 2 weeks after their discontinuation. The use of zidovudine. Children under 12 years.
Precautions:
Use with caution in patients with hepatic or renal failure, hemochromatosis, bronchial asthma and a low-fat diet. The medicine contains 167 mg sodium per dose, which should be taken into account in patients with reduced renal function and in patients who control sodium in the diet. The product contains paracetamol; because of the risk of overdose, it should be checked if the drugs taken do not contain paracetamol. While taking the drug should not drink alcohol because of the increased risk of toxic liver damage, especially in people who are starved and regularly drinking alcohol.
Pregnancy and lactation:
During pregnancy and breastfeeding, use only if definitely needed. Paracetamol passes through the placenta and into the milk of breast-feeding women in an amount of about 1% of the dose taken by the mother. Ascorbic acid also crosses the placenta and into milk.
Side effects:
Uncommon: erythema, urticarial skin reactions and redness of the skin. Rare: allergic reactions such as Quincke's edema, shortness of breath, bronchospasm, confluent sweat, low blood pressure up to symptoms of shock, nausea, vomiting. Very rare: autoimmune thrombocytopenia, leukopenia, agranulocytosis, granulocytopenia, neutropenia, haemolytic anemia, liver damage, renal colic, renal papillary necrosis, acute renal failure, urolithiasis.
Dosage:
Orally. Adults and adolescents over 12 years: 1 tabl. every 4-6 h. The maximum dose is 3 tablets. per day.Way of giving. The tablet should be dissolved in 1/2 glass of water.
(C)
