the product in the database has an inactive status
indications:
Emergency treatment of colds, influenza, flu-like symptoms, rhinosinusitis (fever, runny nose cough, head and throat pain, myalgia and osteoarticular pain).
Composition:
1 tabl cover contains 325 mg of Paracetamol, 30 mg of pseudoephedrine hydrochloride, 10 mg of dextransorfan hydrobromide.
Action:
The preparation has analgesic, antipyretic, antitussive, restoring the patency of the nasal passages and paranasal sinuses.paracetamol has analgesic and antipyretic properties. Inhibits the synthesis of prostaglandins in the central nervous system (o.u.n.) by inhibiting the activity of arachidonic acid cyclooxygenase. It reduces the sensitivity o.u.n. for kinin and serotonin, which increases the pain threshold. The reduction in the concentration of prostaglandins in the hypothalamus causes antipyretic effects. It does not inhibit platelet aggregation. Rapidly and almost completely absorbed from the gastrointestinal tract, the maximum concentration in the blood after oral administration occurs after about 1 hour. It is slightly bound to plasma proteins by approx. 25%, T0,5 is 1.6-8.8 h. The basic route of elimination is biotransformation in the liver, only a small part (2-4%) is excreted unchanged by the kidneys. The hepatotoxic intermediate metabolite (N-acetyl-p-benzoquinoline) formed in a small amount (5%) is coupled with glutathione and then excreted in urine in combination with cysteine and mercapturic acid. Hepatic glutathione resources may be depleted causing the accumulation of a toxic metabolite in the liver, which may lead to hepatocyte damage and necrosis and acute hepatic failure.pseudoephedrine is a dexisomer of ephedrine, showing approximately 1 of its potency on blood vessels and 1 of its potency to expand to the bronchi. It stimulates the α-adrenergic receptors of the smooth muscle blood vessels, resulting in contraction of the end arterioles and decreases the congestion of the nasal mucosa. It is absorbed quickly and completely from the gastrointestinal tract. The maximum serum concentration occurs after 1.5 hours. The decongestant effect occurs after 30 min. and it lasts up to 4 hours. In 70-90% it is excreted unchanged in the urine.dextromethorphan is the D-isomer of the codeine analogue, levorphanol. It acts on the center of cough in the medulla cortex by reducing the sensitivity of receptors to stimuli from the airways. Dust is absorbed from the gastrointestinal tract. Cmax occurs after 2 h (after taking the 30 mg dose). The maximum effect occurs after approx. 15-30 minutes. The effect lasts up to 4 hours. It is metabolised in the liver, excreted unchanged and metabolites in the urine (up to 56% of the administered dose).
Contraindications:
Hypersensitivity to any component of the preparation. Concomitant use of other paracetamol-containing medicines. The use of MAO inhibitors and up to 2 weeks from discontinuation. Congenital deficiency of glucose-6-phosphate dehydrogenase. Severe renal or hepatic failure. Severe hypertension. Ischemic heart disease. Alcoholic disease. Bronchial asthma. Breastfeeding period. Do not use in children <6 years.
Precautions:
The use of the drug by people with liver failure, alcohol abuse and starved poses a risk of liver damage. Caution in patients with renal failure, hypertension, arrhythmias, emphysema, increased intraocular pressure, prostatic hyperplasia, hyperthyroidism, diabetes mellitus and those using anticoagulants, anxiolytics, tricyclic antidepressants, other sympathomimetic drugs, i.e. hyperemia, appetite suppressant and amphetamine-like psychostimulants. Do not use in case of chronic cough with excretion of secretion. Do not use in patients with respiratory insufficiency, bronchial asthma or in patients at risk of respiratory distress. You must not drink alcohol while taking the preparation.
Pregnancy and lactation:
The preparation can be used during pregnancy only in cases where the benefit for the mother outweighs the potential risk to the fetus. Do not use during breast-feeding.
Side effects:
The following may occur: drowsiness, dizziness; hallucinations; fatigue; cutaneous allergic reactions, redness of the skin, rash; angioneurotic edema, anaphylactic reaction (dyspnoea, excessive sweating, low blood pressure up to shock symptoms); bronchial asthma attack; nausea, vomiting; liver damage; acceleration of heart rate; slight increase in pressure; granulocytopenia, agranulocytosis, thrombocytopenia; renal colic, renal papillary necrosis, acute renal failure, urolithiasis, urinary disorders, urinary retention, especially in patients with prostatic hyperplasia.
Dosage:
Orally. Adults and adolescents aged> 12 years: 2 tablets 3-4 times a day. Do not use doses higher than 8 tablets / day. Children aged 6-12: 1 tabl. 3-4 times a day. Do not exceed 4 tablets / day.
(C)
