Symptoms that occur during colds and flu, for example: headache, sore throat, fever, malaise (fatigue, weakness), muscle pain. Toothache, bone and joint pain, migraine, menstrual pain.
Composition:
1 tabl Effervescent contains 500 mg of Paracetamol and 65 mg of caffeine. The preparation contains: aspartame, sorbitol, sodium.
Action:
An analgesic and antipyretic preparation containing paracetamol and caffeine. Paracetamol inhibits the biosynthesis of prostaglandins by inhibiting arachidonic acid cyclooxygenase at o.u.n. Only slightly inhibits peripheral cyclo-oxygenase enzyme, without causing damage to the gastric mucosa. Paracetamol does not affect platelet aggregation. Caffeine stimulates o.u.n., enhances the analgesic effect of paracetamol and has a weak diuretic effect. Caffeine relieves malaise (fatigue, weakness, lack of vigilance), often associated with colds and flu.
Contraindications:
Hypersensitivity to the components of the preparation. Alcoholic disease. Severe hepatic or renal failure. Heart arythmia. Insomnia. Disorders associated with hereditary fructose intolerance. The drug should not be given to children under 12 years of age.
Precautions:
Due to the risk of overdose, patients should be advised not to take the product together with other medicines containing paracetamol. To be used with caution in patients with hepatic and renal insufficiency, deficient in glucose-6-phosphate dehydrogenase and methemoglobin reductase. Do not drink alcohol while taking the drug due to the increased risk of liver damage. The special risk of liver damage exists in patients who are starved and regularly drink alcohol. When using the preparation, excessive consumption of caffeine (eg contained in coffee, tea and some beverages) should be avoided. The preparation contains aspartame (source of phenylalanine) - it may be harmful for patients with phenylketonuria. The preparation contains 427 mg sodium per tablet, this should be taken into account in patients with reduced renal function and in patients who control sodium content in the diet. The preparation contains sorbitol - do not use in patients with rare hereditary fructose intolerance.
Pregnancy and lactation:
Medicines containing paracetamol and caffeine should not be used during pregnancy due to possible increased risk of spontaneous abortion associated with caffeine intake. Paracetamol and caffeine penetrate into breast milk. Studies carried out among lactating women did not show the harmful effects of paracetamol taken at the recommended doses on a fed baby. Caffeine found in breast milk may potentially have a stimulating effect on a breastfed child, but no significant toxic effects have been observed. The drug should be used during breastfeeding if necessary.
Side effects:
Paracetamol. Very rare: thrombocytopenia, anaphylactic reactions, skin hypersensitivity reactions including skin rash, angioneurotic edema and Stevens-Johnson syndrome (bullous erythema multiforme); bronchospasm in patients with hypersensitivity to Acetylsalicylic acid and other NSAIDs; liver dysfunction.Caffeine. Frequency unknown: nervousness, dizziness. In the case where the preparation containing paracetamol and caffeine will be administered in the recommended dosage in combination with caffeine contained in food, it is possible to increase the side effects associated with the increase in total caffeine dose (ie: insomnia, restlessness, anxiety, irritability, headaches, disorders gastrointestinal palpitations).
Dosage:
Orally. Adults and children over the age of 12: 1-2 tabl. up to 4 times a day, not more often than every 4 hours. The maximum daily dose is 8 tablets. (equivalent to 4000 mg of paracetamol and 520 mg of caffeine). You should not use it regularly for more than 3 days without consulting your doctor. If symptoms persist, seek medical advice. Do not take other medicines containing paracetamol.Before serving, the tablet should be dissolved in at least half of the glass of water.
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