Index of drugs

Migraine attacks. Vascular headaches, if analgesics are ineffective.

1 tabl the coated mite contains 0.5 mg of ergotamine tartrate and 25 mg of anhydrous caffeine; 1 tabl the coated forte contains 1 mg of ergotamine tartrate and 100 mg of anhydrous caffeine.

Antimigraine drug combining the action of ergotamine with caffeine. Caffeine increases the absorption of ergotamine from the gastrointestinal tract. Ergotamine has a strong vasoconstrictor effect, but it can also cause vasodilatation depending on the vascular resistance. If the vascular resistance is small, ergotamine causes contraction and increase in blood pressure; if the vascular resistance is high, ergotamine causes vasodilatation. A direct alkaloid effect on serotonin receptors is probably responsible for the contracting effect. In migraine headaches, ergotamine is likely to cause selective contraction of the cranial arteries and exerts a central inhibitory effect on serotoninergic neurons mediating transmission or regulation of the conduction of pain stimuli. Ergotamine also works via α-adrenergic receptors and exerts strong oxytocic effects. Caffeine blocks the A1 and A2 receptors of neurons. The mechanism of action of caffeine is related to the inhibition of the phosphodiesterase enzyme and the increase of adenosine cellular activities. In therapeutic doses, stimulates the activity of the cerebral cortex and vegetative centers. It improves concentration, reduces reaction time, improves the ability to think, relieves symptoms of mental fatigue, reduces sleepiness. Caffeine extends the extracranial and intracranial vessels. It speeds up the activity, increases the strength of contractions and the capacity of the ejection of the heart. Caffeine enhances the effect of painkillers. After oral administration, the bioavailability of ergotamine is below 5%. The mean maximum concentration of ergotamine in the serum occurs after 0.5-2 h. Ergotamine is metabolised in the liver, metabolites are excreted in the bile (up to 90%). Medium T_0,5 ergotamine is 2-2.5 hours. Caffeine is well absorbed from the gastrointestinal tract. Maximum serum concentration occurs after 15-45 min. T_0,5 caffeine is 3-5 hours in adults; in children it is much longer - 36-144 h.

Hypersensitivity to ergot alkaloids or any of the preparation ingredients. Uncontrolled hypertension, peripheral vascular disease such as Raynaud's disease, obliterative vasculitis, thrombophlebitis, advanced atherosclerosis, vascular surgeries, myocardial ischemia, previous myocardial infarction. Peptic ulcer of the stomach and duodenum. Diseases of the kidneys and liver. Sepsis. Glaucoma. Pregnancy and breastfeeding.

The preparation should be used with caution in patients with arrhythmias. In the case of tingling in the fingers or toes, the drug should be discontinued. Ergotamine may react with plastics used for reconstruction in surgery. The preparation is not intended for long-term therapy and should not be used in the prevention of migraine. Prolonged use of any painkillers may cause headache. If such a cause of headache occurs or is suspected, the drug should be discontinued. In patients who have frequent or daily headaches despite (or because of) regular use of anti-acne medications, consideration should be given to diagnosing a headache depending on the continued use of medications. The product contains lactose - should not be used in patients with rare hereditary galactose intolerance, Lapp lactase deficiency or malabsorption of glucose-galactose.

Do not use the product during pregnancy and breastfeeding.

Nervous system disorders: ergotamine - disorders on the part of o.u.n. such as: paresthesias of peripheral body parts, weakness of the limbs, pain and dizziness, confusion, drowsiness; caffeine - insomnia, irritability, muscle tremors.Disorders of the heart and blood vessels: arrhythmia, myocardial fibrosis, valvular, coronary and aortic vessels, increase or decrease in blood pressure; Long-term use of ergotamine, especially at higher doses, may lead to ergotism (initially manifested by the cooling of hands and feet, and in the Next stage limitation of circulation in the limbs, long-lasting contraction of limbs and consequent necrosis of limbs). Gastrointestinal disorders: nausea, gastrointestinal discomfort, epigastric pain, constipation, gingival hypertrophy; in addition, ergotamine may cause: ischemia, irritation, bleeding and ulceration of the anus, caused by vasospasm. During long-term use of the preparation, damage to the liver and / or kidneys may occur. In addition, the preparation may cause muscle tension disorders (preceded by paresthesias, spasms, lower limb pain), erythema, edema, ecchymosis, epidermal necrolysis, and acne.
During the use of the preparation, very individual hypersensitivity reactions to ergotamine may occur. Cases of myocardial ischemia have been described, as well as cases of myocardial infarction during treatment with even low doses of ergotamine (2 mg per week). Peripheral vascular disorders may occur even after a single dose of ergotamine.

Orally.Coffecorn mite: adults and children over 12 years: 1-4 tabl. at the time of the first prodromal symptoms. Then, if it is necessary to interrupt the onset of migraine - 1-2 tabl. every 1/2 hour (maximum of 8 tables per day or 16 tables per week). At least 4 days should be allowed between successive maximum doses. Other vascular headaches: 1-2 tabl. 2 times a day, not longer than 4 days.Coffecorn forte: adults and children over 12: 1-2 tabl. at the time of the first prodromal symptoms. Then, if it is necessary to interrupt the onset of a migraine - 1 tabl. every 1/2 hour (maximum 4 tables per day or 8 tables per week). At least 4 days should be allowed between successive maximum doses. Other vascular headaches: 1 tablet 2 times a day, not longer than 4 days.