Pains of various origins of low and moderate severity (eg headache, rheumatic pains, muscle pain, neuralgia, toothache).
Composition:
1 tabl contains 450 mg of Acetylsalicylic acid and 50 mg of caffeine.
Action:
The preparation with the combined action of ingredients: analgesic, anti-inflammatory, antipyretic and analeptic. Acetylsalicylic acid suppresses the synthesis of prostaglandins and thromboxane A2. In addition, it reduces platelet aggregation. It is quickly absorbed from the digestive tract - partly from the stomach, mainly from the intestines. The rate of absorption depends on the pH of the content. It binds to plasma albumin at 50-80%. It easily penetrates into tissues and through the placenta barrier. It is metabolized in the liver and excreted in urine in 10% in unchanged form and in the form of metabolites. T0,5 is 2-3 h. The Caffeine contained in the preparation is quickly absorbed from the gastrointestinal tract, is metabolized in the liver and excreted in the form of metabolites in the urine. It has a stimulating effect on vegetative centers: respiratory and vasomotor. It passes through the blood-brain barrier, through the placenta and into breast milk.
Contraindications:
Hypersensitivity to the preparation ingredients or salicylates. Past bronchial asthma attacks - after salicylates or other NSAIDs. Peptic ulcer of the stomach and / or duodenum, gastrointestinal bleeding, haemorrhagic diathesis, gout. Severe liver or kidney problems. Severe heart failure. Co-administration with Methotrexate at doses ≥ 15 mg per week. Pregnancy and breastfeeding. Children up to 12 years.
Precautions:
Caution in patients receiving anticoagulants and those who are hypersensitive to salicylates and NSAIDs. Use with caution in patients with peptic ulcer or history of gastrointestinal bleeding, G-6-PD deficiency, hyperthyroidism and hypertension. Caution should be exercised in patients with allergic diseases (bronchial asthma, hay fever with nasal polyps), prior to surgery, impaired renal and hepatic function, in the presence of heavy menstrual bleeding and in women using intrauterine contraceptives.
Pregnancy and lactation:
The preparation is contraindicated in pregnancy and breast-feeding. Acetylsalicylic acid, by affecting ovulation, may affect fertility in women. This effect is transient and disappears after discontinuation of the preparation.
Side effects:
Abdominal pain, heartburn, nausea, vomiting, gastrointestinal bleeding (overt or latent), gastric and duodenal ulcer, perforation, headache and dizziness, tinnitus, insomnia, restlessness, increased risk of bleeding, prolonged bleeding time and prothrombin time, thrombocytopenia, urticaria, skin reactions, anaphylactic reactions, bronchial asthma, angioneurotic edema, arrhythmias. Rare: liver dysfunction, renal papillary necrosis, interstitial nephritis.
Dosage:
Orally. Adults and children over 12 years of age: 1 tabl. 2-6 times a day, not more often than every 4 hours. Do not use long-term, do not take on an empty stomach. Do not exceed 6 tables per day. The tablets are sipped with plenty of liquid.
(C)
