Medium and high-intensity pains that do not affect painkillers with peripheral action. Paracetamol with codeine does not work on phantom, neurogenic pain.
Composition:
1 tabl contains 500 mg of paracetamol and 30 mg of codeine phosphate.
Action:
A combined preparation containing paracetamol and codeine. Paracetamol has an analgesic and antipyretic effect, mainly by inhibiting the activity of prostaglandin cyclooxygenase at o.u.n. It is well absorbed from the gastrointestinal tract, the maximum concentration in blood reaches after about 30-60 min, it penetrates into body fluids and internal organs. T0,5 is about 2 hours. It is metabolized in the liver and excreted in the urine in the form of glucuronides and sulphates. Paracetamol crosses the placenta. Codeine has analgesic and antitussive effects. It is easily absorbed from the gastrointestinal tract. T0,5 is about 3 hours. It is metabolized in the liver. It excretes in the urine mainly in the form of glucuronides. It passes through the placenta and into breast milk.
Contraindications:
Hypersensitivity to the components of the preparation. Hepatic failure, severe renal failure, bronchial asthma or respiratory failure, G-6-PD deficiency, alcoholism. Treatment with MAO inhibitors and up to 2 weeks after discontinuation, concomitant use of drugs with agonist-antagonist activity (buprenorphine, nalbuphine, pentazocine). The preparation should not be used in patients who are secretion-secreting. I trimester of pregnancy and the period of pregnancy feeding. Children up to 15 years of age.
Precautions:
Use with caution in patients with head injuries, liver or kidney problems, and chronic respiratory diseases. Codeine can cause colic attacks in patients with cholelithiasis or urinary calculi and urinary retention in patients with prostate hyperplasia. The use of the preparation by alcohol-abusing patients and starved people increases the risk of liver damage. Due to its pharmaceutical form, the preparation should not be used in elderly patients (it is not possible to divide the tablet and give the recommended dose).
Pregnancy and lactation:
The preparation is contraindicated in the first trimester of pregnancy. In the second and third trimester of pregnancy, single doses of the preparation can be used only in extreme necessity - high doses of codeine, even if used temporarily in the perinatal period, may cause inhibition of the respiratory center in the newborn; long-term use of codeine in the third trimester of pregnancy may be the cause of withdrawal syndrome in the newborn, regardless of the dose. During breast-feeding, the drug is contraindicated - codeine is excreted in breast milk.
Side effects:
There may be nausea, vomiting, constipation, renal colic, renal papillary necrosis, acute renal failure, drowsiness, dizziness, inhibition of the respiratory center, apnea. Rare hypersensitivity reactions: redness of the skin, rash, erythema or urticaria, angioedema, dyspnea, bronchospasm, increased sweating, low blood pressure up to shock. Granulocytopenia, thrombocytopenia and agranulocytosis have been observed very rarely. During long-term use, there is an increased risk of addiction and withdrawal syndrome in patients who have suddenly stopped using the preparation and in newborns whose mothers took the medicine during the third trimester of pregnancy.
Dosage:
Orally. Adults: 1-2 tabl. 1-3 times a day; the maximum daily dose is 6 tablets In patients with renal insufficiency, the interval between consecutive doses should be at least 8 hours. The tablet should be drunk with plenty of water.
(C)
