Dolargan, Chinoin Pharmaceutical and Chemical Works Private
the product in the database has an inactive status
indications:
Strong, long-lasting pain that does not go away after using non-narcotic analgesics (post-operative pain, injuries, cancer pain). Premedication before surgery, reducing the amount of anesthetic. Pain in acute myocardial infarction, pulmonary edema in acute left ventricular failure. Liver and renal colic (in cases when administration of non-narcotic analgesics and high doses of diastolic drugs is insufficient).
Synthetic, opioid analgesic, a pure agonist of opioid receptors (mi, kappa and delta). Has a cholinolytic effect. Fewer than morphine, it has a contraction effect on the smooth muscle of the gastrointestinal tract, it has a lower tendency to induce constipation and increase pressure in the urinary and biliary tracts. It does not relieve cough. It does not inhibit the uterine contraction function, it penetrates the placenta to a lesser extent from morphine, it passes into breast milk. In the usual doses, it does not narrow the pupils (it may dilate). It is well absorbed after subcutaneous or intramuscular administration - the onset of action occurs after 10-15 min, the analgesic effect lasts about 2-4 h. The degree of binding to plasma proteins is 58 ± 9%. The drug is metabolised in the liver. Most of the medicine is excreted in the urine in unchanged form and in the form of metabolites. T0,5 is 3.2 ± 0.8 hours.
Contraindications:
Hypersensitivity to the drug. Respiratory failure. Skull injuries with the possibility of intracranial hypertension. Concomitant use of MAO inhibitors (can be used 2 weeks after the end of MAO inhibitors). Use during an attack of bronchial asthma and acute abdominal pains before establishing the diagnosis. Breast-feeding.
Precautions:
Caution should be exercised and lower doses should be used in weakened patients with severe renal and / or renal failure, adrenocortical insufficiency, hypothyroidism and prostatic hyperplasia.
Pregnancy and lactation:
It can be used during pregnancy after considering the benefits and risks to the fetus. For the relief of labor, it can be used after careful consideration of the benefits and risks - optimally with the opioid receptor antagonist to prevent depression of the neonatal respiratory system. Do not use when breastfeeding (it passes into breast milk).
Side effects:
The most serious side effect is the inhibitory effect on the respiratory system. In addition, you may experience: nausea, vomiting, constipation, dry mouth, pain and dizziness, blurred vision, uncoordinated muscle movements, muscle tremors, agitation, euphoria, confusion, hallucinations, dysphoria, severe seizures, facial flushing, tachycardia, bradycardia, palpitations, hypotension, urinary retention, fainting (accompanied by heavy sweating), itching, urticaria, other skin reactions, blisters and redness of the skin at the injection site. Taken for a long time, it causes drug (opioid) dependence, suddenly withdrawn - abstinence syndrome.
Dosage:
Adults: subcutaneously or intramuscularly 50-100 mg 1-3 times a day; if necessary intravenously slowly (2-3 min) 25-100 mg diluted in 10 ml of 10% Glucose or 0.9% NaCl. Children from 2 months to 14 years: a single subcutaneous dose is 1 mg / kg. In combination with chlorpromazine and prometazine - 2 mg / kg In the case of renal impairment (GFR 10-50 ml / min), 75% of the usual dose is used, with GFR below 10 ml / min half of the usual dose is used. In elderly patients, use the lowest effective starting dose, subsequent doses can be increased after clinical evaluation. Doses should be reduced in patients with severe liver damage, adrenocortical insufficiency, hypothyroidism, and prostatic hypertrophy.
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