Index of drugs

Strong pain, eg headaches of various origins (eg migraines), muscle and joint pain, toothache, neuralgia. Pain and fever in the course of colds and flu.

1 tabl Effervescent contains 1000 mg of acetylsalicylic acid.

A non-steroidal anti-inflammatory drug with analgesic, anti-inflammatory and antipyretic properties. The mechanism of action consists in inhibiting the synthesis of prostaglandins - PGE2, PGI2 and thromboxane A2 - due to the inhibition of arachidonic acid cyclooxygenase (COX-1 and / or COX-2). Many data indicate that a central mechanism of analgesic action is also possible. Acetylsalicylic acid also inhibits platelet aggregation. Acetylsalicylic acid is absorbed from 80-100% of the gastrointestinal tract; food does not reduce bioavailability, but it can extend the absorption time. The rate of absorption of acetylsalicylic acid from soluble forms is greater than that of conventional forms. The analgesic and antipyretic effects of the preparation start after 30 minutes from the moment of application, reaching a maximum after 1-3 hours. After a single dose, it is maintained for 3-6 h. Full anti-inflammatory action occurs within 1-4 days of treatment. Approx. 33% of the drug binds to proteins if the serum concentration is 120 μg / ml. The degree of protein binding depends on the albumin concentration. Acetylsalicylic acid is hydrolyzed in plasma to salicylic acid, which is coupled in the liver to salicylic acid, phenolic and acyl glucuronide and many other metabolites. T_0,5 acetylsalicylic acid in the plasma is about 2-3 h, and salicylic acid about 6 h. Only about 1% of the oral dose of acetylsalicylic acid is excreted in the urine in a non-hydrolyzed form, the remaining part is excreted in the urine in the form of salicylic acid and its metabolites.

Hypersensitivity to the active substance or any of the excipients (hypersensitivity to acetylsalicylic acid occurs in 0.3% of the population, including 20% ​​of patients with bronchial asthma or chronic urticaria; symptoms of hypersensitivity: urticaria and even shock may occur within 3 hours of taking the drug). Hypersensitivity to other NSAIDs, with symptoms such as: bronchospasm, rhinitis, shock. Bronchial asthma, chronic respiratory disease, hay fever or nasal edema (patients with these diseases may respond to NSAIDs with asthma attacks, limited by swelling of the skin and mucous membrane (angioneurotic edema) or urticaria more often than other patients). Active peptic ulcer of the stomach and / or duodenum and inflammation or bleeding from the gastrointestinal tract (gastrointestinal bleeding or ulcer disease). Severe hepatic or renal failure. Severe heart failure. Blood coagulation disorders (eg haemophilia, thrombocytopenia) and concomitant treatment with anticoagulants (eg coumarin derivatives, heparin). G-6-PD deficiency. Co-administration with Methotrexate in doses of 15 mg per week or more, due to myelotoxicity. Children and adolescents (under 18 years of age) due to the risk of Reye's syndrome. III trimester of pregnancy and breastfeeding.

Acetylsalicylic acid should be used with caution: in the case of hypersensitivity to non-steroidal anti-inflammatory and anti-rheumatic drugs or other allergenic substances; during the simultaneous use of anticoagulants; in patients with peptic ulcer or history of gastrointestinal bleeding; in patients with impaired renal function and chronic renal failure (in patients with reduced uric acid excretion the preparation may cause gout); in patients with juvenile rheumatoid arthritis and / or systemic lupus erythematosus and impaired hepatic function (these patients should be monitored for liver function); when co-administered with methotrexate at doses lower than 15 mg / week(due to the increased toxicity of methotrexate on the bone marrow); in the case of uterine haemorrhage, excessive menstrual bleeding, use of the IUD, hypertension and heart failure; in elderly patients (the product should be used at lower doses and at longer intervals due to the increased risk of side effects). It must not be used in patients who are taking oral anti-diabetic medicines from the sulphonylurea group because of the increased risk of hypoglycaemic effects and in patients taking anticonivirals. Acetylsalicylic acid should be discontinued 5 to 7 days before the planned surgery, due to the risk of prolonged bleeding time both during and after the procedure. Acetylsalicylic acid can cause bronchospasm and trigger asthma attacks or other hypersensitivity. Risk factors include: bronchial asthma, chronic respiratory diseases, allergic rhinitis, nasal polyps. This warning also applies to patients with allergic reactions (skin reactions, pruritis, urticaria) to other substances.

Acetylsalicylic acid should not be used in women in the first and second trimesters of pregnancy unless it is absolutely necessary. If acetylsalicylic acid is used by women attempting to become pregnant or during the first and second trimester of pregnancy, the lowest possible dose should be used for as short a period as possible. Data from epidemiological studies indicate an increased risk of miscarriage and the occurrence of heart defects and gastrointestinal defects associated with the use of prostaglandin synthesis inhibitors in the early weeks of pregnancy. Acetylsalicylic acid in doses of 100 mg / day or more is contraindicated in the third trimester of pregnancy. Acetylsalicylic acid and its metabolites are excreted in breast milk in small amounts. Because so far, during the short-term use of salicylates by mothers, no side effects were found in breastfed infants, interruption of breastfeeding is usually not necessary. However, if you regularly take high doses of Acetylsalicylic acid, breast-feeding should be stopped earlier. There is evidence that cyclooxygenase-inhibiting drugs can cause fertility problems in women by affecting ovulation. This effect is transient and disappears after completion of therapy.

The following may occur: thrombocytopenia, anemia due to gastrointestinal bleeding, hemolytic anemia in patients with G-6-PD deficiency, leukopenia, agranulocytosis, eosinopenia, increased risk of bleeding, prolonged bleeding time, prolonged prothrombin time, dizziness and tinnitus (usually symptoms of overdose), visual impairment, impaired hearing, reversible hearing loss, dizziness, heart failure, cerebral hemorrhage (especially in patients with uncontrolled hypertension and / or concomitant use of other anticoagulants), extracardiac pulmonary edema (mainly in chronic or acute poisoning), bronchial asthma, dyspepsia, heartburn, epigastric fullness, nausea, vomiting, lack of appetite, abdominal pain, gastrointestinal bleeding, gastric mucosal damage, peptic ulcer of the stomach or duodenum, perforation (ulcer stomach and occurs in 15% of patients on long-term acetylsalicylic acid), focal liver cell necrosis, tenderness and hepatomegaly (especially in patients with juvenile rheumatoid arthritis, systemic lupus erythematosus, rheumatic fever or a history of liver disease), transient increase in serum transaminases , alkaline phosphatase and bilirubin, skin eruptions of various kinds, rarely bladder or purpura, proteinuria, presence of leukocytes and erythrocytes in the urine, renal papillary necrosis, interstitial nephritis, fever, hypersensitivity reactions with clinical symptoms and abnormal results of appropriate laboratory tests such as: asthma, mild to moderate reactions involving the skin, respiratory system, cardiovascular system with symptoms such as rash, urticaria, edema (including vasomotor), respiratory and heart problems, enthusiasts e of the nasal mucosa, nasal congestion and very rarely severe reactions, including anaphylactic shock (hypersensitivity to acetylsalicylic acid occurs in 0.3% of the population and in 20% of patients with bronchial asthma or chronic urticaria; symptoms of hypersensitivity: urticaria and even shock may occur within 3 hours of taking the medicine). Prolonged intake of medicines containing acetylsalicylic acid may cause a headache that worsens when taking subsequent doses.

Orally. Adults: 1 tabl. once a day.If necessary, the dose can be repeated from 2 to 3 times a day. Do not exceed the dose of 3 g per day. The lowest effective dose should be used. Symptomatic treatment should not last longer than 3 days. Before use, dissolve the tablet in 3/4 glass of water.