Short-term treatment of cold and flu symptoms such as fever, chills, headache, muscle pain, sore throat, runny nose, sinus pain.
Composition:
1 sachet contains 750 mg of Paracetamol, 60 mg of Ascorbic acid and 10 mg of phenylephrine hydrochloride. The product contains sucrose.
Action:
The preparation combines the action of individual ingredients. Paracetamol has analgesic and antipyretic effects. It inhibits the activity of arachidonic acid cyclooxygenase. The effect of this action is to reduce the sensitivity to such mediators as kinins and serotonin, resulting in an increase in the pain threshold. The reduction in the concentration of prostaglandins in the hypothalamus is responsible for the antipyretic effect. Paracetamol is quickly and almost completely absorbed from the gastrointestinal tract. After oral administration it reaches Cmax after about 1 hour. The main route of elimination is its biotransformation in the liver. The main metabolite of paracetamol in adults is glucuronide and in children - sulphate. In addition to sulphate and glucuronide, an indirect metabolite, N-acetyl-p-benzoquinone, is formed with the participation of the cytochrome P-450 oxidative system. This hepatotoxic metabolite is immediately bound to hepatic glutathione and then excreted in combination with cysteine or mercaptopurine. T0,5 paracetamol is 2-4 h. Phenylephrine is a postsynaptic stimulator of α-adrenergic receptors. It has a decongestant effect on peripheral vessels, reducing swelling of mucous membranes. The digestive tract is absorbed to a small extent, the bioavailability is 38%. It is extensively metabolised in the wall of the small intestine. It is mainly excreted in the urine. T0,5 it is 2-3 h. The addition of ascorbic acid serves to supplement the shortages that often appear in the course of cold diseases.
Contraindications:
Hypersensitivity to the components of the preparation. Hypertension. Aneurysms. Hyperthyroidism. Heart diseases. Severe renal failure. Liver failure. Diabetes. Congenital deficiency of glucose-6-phosphate dehydrogenase. Glaucoma with a narrow angle of perception. Phenylketonuria. Alcoholic disease. Treatment with MAO inhibitors and up to 2 weeks after discontinuation. Treatment with β-blockers. Treatment with tricyclic antidepressants. Pregnancy and breastfeeding. Children aged <12 years.
Precautions:
Particularly cautiously use in patients with renal failure, active peptic ulcer disease, prostatic hyperplasia, elevated intraocular pressure, pheochromocytoma, as well as in patients responsive to hypersensitivity to Acetylsalicylic acid and those treated with sedatives and sympathomimetics. Caution should be exercised in patients taking anticoagulants and in the elderly. Use of the preparation in people with liver dysfunction, alcohol abusers and starved people poses a risk of liver damage. Do not use together with other medicines containing paracetamol. Due to the sucrose content, the preparation should not be used in patients with fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase deficiency.
Pregnancy and lactation:
The preparation is contraindicated in pregnancy and breast-feeding.
Side effects:
In individual cases may occur: neutropenia, thrombocytopenia, agranulocytosis, headache and dizziness, bronchial asthma attack, nausea, vomiting, symptoms of liver damage, liver failure, renal colic, renal papillary necrosis, acute renal failure, urolithiasis, impaired urination , urinary retention (especially in patients with prostatic hyperplasia), urticaria, rash, erythema, angioneurotic edema, slight increase in blood pressure, increased heart rate, low blood pressure to symptoms of shock.
Dosage:
Orally. Adults and children> 12 years: 1 sachet every 4-6 hours. Do not use more than 4 sachets daily. Before taking the powder, dissolve in a glass of hot water.
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