Short-term treatment of low to moderate pain. 50 mg suppositories: pain associated with serration; fever, e.g. in the course of childhood diseases in patients who can not take Paracetamol orally, e.g. due to nausea or vomiting; suppositories 125 mg and 500 mg: headache, toothaches, muscular, joint and bone pain, pain after surgical and dental procedures; fever, for example in the course of colds or flu, in patients who can not take paracetamol orally, e.g. because of nausea or vomiting.
Composition:
1 suppository contains 50 mg, 125 mg or 500 mg of paracetamol.
Action:
Paracetamol is a medicine with analgesic and antipyretic effect. It inhibits the synthesis of prostaglandins in the central nervous system by inhibiting arachidonic acid cyclooxygenase. The reduction in the concentration of prostaglandins in the hypothalamus is responsible for the antipyretic effects of paracetamol. Paracetamol does not inhibit prostaglandin synthesis in peripheral tissues. The duration of analgesia is 4-6 h and the antipyretic effect is 6-8 h. Paracetamol is well absorbed after rectal administration. The degree of binding to plasma proteins is about 25-28%. T0,5 in the phase of elimination in adults it is about 3-4 hours, in children it ranges from 1.4-4.5 hours. Paracetamol is metabolised in the liver, 90% of the taken dose is excreted in the urine in the form of glucuronides and sulphates, 5% unchanged, the remaining 5% are metabolized in the liver, mainly by CYP2E1 to the reactive hepatotoxic metabolite, N-acetylbenzoquinamine (NAPQI). NAPQI undergoes a coupling reaction with glutathione or other substances containing a thiol group of substances to form a water-soluble mercapturic acid, thus easily excreted.
Contraindications:
Hypersensitivity to the components of the preparation. Severe renal failure. Congenital deficiency of glucose-6-phosphate dehydrogenase and methemoglobin reductase. Severe hepatic failure. Alcoholic disease. And trimester of pregnancy.
Precautions:
During use, check that other medicines do not contain paracetamol. Should be used with caution in elderly patients, in patients with liver or kidney failure. When using Paracetamol, you should not drink alcohol because of the risk of severe liver damage. There is a special risk of liver damage in starved and regular drinkers.
Pregnancy and lactation:
It should not be used during the first trimester of pregnancy. Paracetamol can be used in the second and third trimester of pregnancy and during breastfeeding in case of extreme necessity.
Side effects:
Rarely: hypersensitivity reactions (redness of the skin, rash, angioneurotic edema, dyspnea, asthma attacks, reduced blood pressure up to shock symptoms); stomach and intestinal disorders (nausea, vomiting); symptoms of liver damage, kidney and urinary disorders (renal colic, renal papillary necrosis, acute renal failure). Very rare: agranulocytosis, thrombocytopenia, methemoglobinemia.
Dosage:
Rectally. 50 mg and 125 mg suppositories: the dose is determined in accordance with bw. a child (on average 10-15 mg / kg). Suppositories 50 mg: infants 3-6 months - 1 suppository once, 7-12 months - 1-2 suppositories once. Suppositories 125 mg: children 1-3 years - 1 suppository once, 4-6 years - 1-2 suppositories once. Suppositories 500 mg: adults and adolescents over 12 years - 1 suppository once. If necessary, the dose can be repeated every 4 hours, no more frequently than 4 times a day.
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