Acetylsalicylic acid has analgesic, anti-inflammatory and antipyretic effects. Irreversibly inhibits arachidonic acid cyclooxygenase, thereby inhibiting the synthesis of prostaglandids, including A2 - which inhibits platelet aggregation. The drug is quickly and completely absorbed from the digestive tract. It is transformed into the active metabolite, salicylic acid, during and after absorption. The maximum concentration of Acetylsalicylic acid occurs after 10-20 min, and salicylic acid after 0.3-2 hours. It is strongly bound to plasma proteins, crosses the placenta and into breast milk. Metabolism occurs in the liver and renal excretion. T0,5 is 2-3 hours.
Contraindications:
Hypersensitivity to Acetylsalicylic acid, other salicylates or other components of the preparation. Hemorrhagic diathesis. Active peptic ulcer of the stomach or duodenum. Bronchial asthma attacks due to the administration of salicylates or substances with similar effects, especially NSAIDs. Co-administration of Methotrexate at doses of 15 mg per week or greater. Severe heart, liver or kidney failure. Third trimester of pregnancy. Do not use in children under 12 years of viral infection (risk of Reye's syndrome).
Precautions:
Use with caution in patients with: hypersensitivity to NSAIDs, anti-rheumatic drugs or other allergenic substances; during the simultaneous use of anticoagulants; with impaired liver or kidney function; with history of peptic ulcer or bleeding from the gastrointestinal tract and with a deficiency of glucose-6-phosphate dehydrogenase. In patients with reduced uric acid excretion, the preparation may cause gout attack.
Pregnancy and lactation:
The product should be used in the first and second trimester of pregnancy only if clearly needed after careful consideration of the benefit / risk ratio. In the third trimester the preparation is contraindicated for use. During the short-term use of the preparation by the mother breast-feeding, no adverse effects were seen in infants, interruption of breastfeeding is usually not necessary. However, in the case of long-term and regular high-dose acetylsalicylic acid, breast-feeding should be stopped earlier. The product may affect fertility through affecting ovulation, this effect is transient and disappears after treatment.
Side effects:
Stomach and stomach ache, heartburn, nausea, vomiting, indigestion, inflammation of the gastrointestinal tract, potential life-threatening gastrointestinal bleeding (overt: retinal vomiting, tarry stools, latent), peptic ulcer of the stomach or duodenum, perforation; dizziness, tinnitus; increased risk of bleeding, haemorrhage (postoperative from the nose, gums, genitourinary tract), hematoma, prolonged bleeding time. prothrombin time, thrombocytopenia; stroke; hypersensitivity reactions (asthma, rash, urticaria, edema, respiratory and cardiac disorders, anaphylactic shock); bronchial asthma; Headache. Rare: liver dysfunction (increase in transaminases); necrosis of renal papilla, interstitial nephritis. The effect of bleeding may be the occurrence of acute or chronic iron deficiency anemia or acute exertional anemia manifested by asthenia, paleness, hypoperfusion, as well as abnormal laboratory results.
Dosage:
Orally. Adults: 500-1000 mg once, if necessary, a single dose can be repeated every 4-8 h. Do not use more than 4 g per day. Children over 12 years: 500 mg once, if necessary, a single dose can be repeated every 4-8 h. Do not use more than 1500 mg daily. Table. take after meals with water.
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