Muscle, joint and bone pain of various origins, headaches, migraine, neuralgia, toothache and menstrual pain; post-traumatic and post-operative pain as well as cancer pains of low or moderate intensity; febrile states resulting from colds, flu and flu-like conditions.
Composition:
1 tabl contains 500 mg of Paracetamol and 50 mg of caffeine.
Action:
A complex drug with analgesic and antipyretic effects. The addition of Caffeine increases the effectiveness of the analgesic effect of paracetamol (achieving a reduction in the equivalent degree of pain is possible after a dose of 40% lower compared to a single-component drug) and accelerates the onset of action. The mechanism of action of paracetamol is the inhibition of prostaglandin cyclooxygenase activity at o.u.n. The result is a loss of sensitivity to mediators, such as kinins and serotonin, which increases the pain threshold. The reduction in the concentration of prostaglandins in the hypothalamus causes antipyretic effects. Quickly and almost completely absorbed from the gastrointestinal tract. The maximum plasma concentration appears after 1 hour. It binds to plasma proteins at 25-50%. T0,5 is 2-4 h. The duration of analgesia is defined as 4-6 h and antipyretic for 6-8 h. It is metabolized in the liver and excreted in the urine. The hepatotoxic intermediate metabolite (N-acetyl-p-benzoquinoline) formed in a small amount (5%) is coupled with glutathione and then excreted in urine in combination with cysteine and mercapturic acid. If you take doses higher than recommended, this mechanism is quickly saturated, which may lead to the accumulation of toxic metabolite and liver damage. Caffeine (methylxanthine, with a chemical structure similar to theophylline) has a stimulating effect on o.u.n.n., which causes a subjective feeling of regression of fatigue, improved coordination and speed of mating. Increases cardiac output and blood flow through coronary vessels, increases diuresis, increases the secretion of gastric juice. Quickly and completely absorbed from the gastrointestinal tract. It binds to 25% of plasma proteins. T0,5 is 3-7 h. It is metabolized in the liver and excreted in the urine. During pregnancy, a slowdown in caffeine metabolism and elevated blood levels was observed at the unspecified dose. It penetrates into breast milk.
Contraindications:
Hypersensitivity to Paracetamol, caffeine or other ingredients of the preparation. Congenital G-6-PD deficiency and methemoglobin reductase. Alcoholic disease. Severe hepatic or renal failure. Heart arythmia. The use of MAO inhibitors and up to 2 weeks after their discontinuation. I trimester of pregnancy and breastfeeding. It should not be used in children <12 years of age.
Precautions:
The use of the drug by people with liver failure, alcohol abuse and starved poses a risk of liver damage. Carefully used in people with renal insufficiency, bronchial asthma, hyperthyroidism, sleep disorders in the form of insomnia. Do not drink alcohol while taking the drug due to the increased risk of liver damage.
Pregnancy and lactation:
It should not be used during the first trimester of pregnancy. In the second and third trimester of pregnancy, use only if the benefit for the mother outweighs the potential risk to the fetus. During pregnancy, the release of caffeine metabolism and higher serum concentrations with no increased dose are observed. It should not be used during breast-feeding.
Side effects:
Rarely observed: agranulocytosis, nausea, vomiting, digestive disorders, cutaneous allergic reactions (urticaria, rash). Very rare: thrombocytopenia, renal colic, renal papillary necrosis, acute renal failure. In addition, you may experience: cardiac acceleration, insomnia, inability to focus, muscular tremors, irritability.
Dosage:
Orally. Adults and children aged> 12 years: 1-2 tabl. every 4-6 h (maximum of 8 tables per day).
(C)
