Short-term relief of symptoms of colds, flu and flu-like infections (such as fever, headache, throat, muscle and osteoarticular pain) and symptoms of nasal edema occurring in colds and flu.
Composition:
1 sachet contains 1000 mg of Paracetamol, 12.2 mg of phenylephrine hydrochloride and 100 mg of ascorbic acid.
Action:
The preparation has a soothing effect on cold, flu and flu-like symptoms.paracetamol it acts as an analgesic and antipyretic agent, by inhibiting the activity of arachidonic acid cyclooxygenase, and thus synthesis of prostaglandins in the central nervous system (o.u.n.). It reduces the sensitivity o.u.n. to the action of kinins and serotonin, which reduces the sensitivity to pain. The reduction in the concentration of prostaglandins in the hypothalamus causes antipyretic effects. It does not affect platelet aggregation. Rapidly and almost completely absorbed from the gastrointestinal tract, the maximum concentration in the blood after oral administration occurs after about 1 hour. It is slightly bound to plasma proteins (10-30%), T0,5 is 2-4 h. The basic route of elimination is biotransformation in the liver, only a small part (2-4%) is excreted unchanged by the kidneys. The hepatotoxic intermediate metabolite (N-acetyl-p-benzoquininoine) formed in a small amount (5%), binds with glutathione, and then, in combination with cysteine and mercapturic acid, is excreted in the urine. Hepatic glutathione resources may be depleted causing the accumulation of a toxic metabolite in the liver, which may lead to hepatocyte damage and necrosis and acute hepatic failure. Phenylephrine is a sympathomimetic amine, causes the release of adrenaline from sympathetic nerve endings and directly stimulates α-adrenergic receptors in the vascular wall. As a result, they shrink and reduce swelling and congestion of the mucous membrane. Phenylephrine hydrochloride is easily and quickly absorbed from the gastrointestinal tract. Due to the intense metabolism in the intestinal wall, bioavailability reaches 40%. The drug achieves a maximum serum concentration after 1-2 h. T0,5 is 2-3 hours. Metabolized in the liver, excreted in the urine. Ascorbic acid participates in the biosynthesis of collagen and intercellular substance and has an antioxidative role. It is necessary in the process of converting cholesterol to bile acids and adrenal steroids. In addition, it participates in the metabolic processes of tyrosine, phenylalanine, folic acid, iron, histamine, noradrenaline, Carnitine, proteins and lipids. Stimulates prostacyclin synthesis, inhibits lipid peroxidation, inactivates superoxide free radicals. He is considered to be a modulator of immunity through participation in the production of immunoglobulins. The digestive tract is absorbed in 70-80%, in 25% bound to plasma proteins. The maximum concentration in plasma reaches after 2-3 h. It is excreted by the kidneys in both the initial form and metabolites.
Contraindications:
Hypersensitivity to active substances, sympathomimetic amines or any of the excipients. Unstable coronary heart disease. Heart arythmia. High blood pressure. Congenital deficiency of 6-phosphate dehydrogenase and mathemoglobin reductase. Severe renal failure. Viral hepatitis. Alcoholic disease. Phenylketonuria (due to the content in the aspartame preparation). Simultaneous treatment with MAO inhibitors and up to 2 weeks after discontinuation of their use, tricyclic antidepressants, zidovudine. Cane with a narrow angle of filtration. Hyperthyroidism. Pregnancy.
Precautions:
Do not use in children <12 years. Do not use with other drugs containing Paracetamol (risk of overdose). Do not use other flu medicines, colds and medicines that reduce mucosal congestion. The use of the drug by people with liver failure, abusing alcohol and starved poses a risk of liver damage.Carefully used in people with: renal insufficiency, bronchial asthma, prostatic hyperplasia, Raynaud's syndrome, diabetes mellitus, coronary heart disease; taking anticoagulants - it is advisable to adjust their dose based on the blood coagulation markers, and if this is not possible, patients taking oral anticoagulants may take the preparation no longer than a few days. The preparation should be used with caution in patients taking ß-adrenergic antagonists. Due to the sucrose content of the preparation should not be used in patients with rare inherited disorders associated with fructose intolerance, malabsorption of glucose-galactose, sucrase-isomaltase deficiency. While taking the preparation, you must not drink alcohol because of the risk of toxic liver damage.
Pregnancy and lactation:
Do not use during pregnancy. There are no data on the safety of use in breastfeeding women.
Side effects:
The following may occur: allergic reactions (pruritis, urticaria); hypersensitivity reactions up to the symptoms of anaphylactic shock; nausea, vomiting, digestive disorders, epigastric burning, dry mouth; increase in blood pressure, tachycardia, arrhythmias, paleness of coatings; breathing disorders, bronchial asthma attack; urination disorders, renal colic, renal papillary necrosis; anxiety, insomnia; hallucinations, anxiety, nervousness; granulocytopenia, agranulocytosis, thrombocytopenia.
Dosage:
Orally. Adults and children> 12 years: 1 sachet every 4-6 hours (maximum 4 sachets daily). The contents of the sachet should be dissolved in a glass of hot water.
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