Index of drugs

Relief of cold symptoms, influenza and flu-like infections, such as fever, headache, throat, muscle and bone-joint pain and symptoms of rhinitis occurring in colds and flu.

1 sachet contains 650 mg of Paracetamol, 10 mg of phenylephrine hydrochloride and 50 mg of ascorbic acid.

The product has a soothing effect on the symptoms of colds, flu and flu-like illness. The mechanism of action of Paracetamol is the inhibition of prostaglandin cyclooxygenase activity at o.u.n. The result is a loss of sensitivity to mediators, such as kinins and serotonin, which increases the pain threshold. The reduction in the concentration of prostaglandins in the hypothalamus causes antipyretic effects. Paracetamol does not affect platelet aggregation. Quickly and almost completely absorbed from the gastrointestinal tract. The maximum concentration in the blood appears after about 1 hour. It binds to plasma proteins in 25-50%. T_0,5 is 2-4 h. The duration of analgesia is defined as 4-6 h and antipyretic for 6-8 h. It is metabolized in the liver and excreted in the urine. The hepatotoxic intermediate metabolite (N-acetyl-p-benzoquinoline) formed in a small amount (5%) is coupled with glutathione and then excreted in urine in combination with cysteine ​​and mercapturic acid. Hepatic glutathione resources may be depleted, which may lead to the accumulation of a toxic metabolite, liver damage, hepatocyte necrosis and acute hepatic failure. Phenylephrine is a sympathomimetic amine, causes the release of adrenaline from sympathetic nerve endings and directly stimulates α-adrenergic receptors in the vascular wall. As a result, they shrink and reduce swelling and congestion of the mucous membrane. Phenylephrine hydrochloride is easily and quickly absorbed from the gastrointestinal tract. Due to the intense metabolism in the intestinal wall, bioavailability reaches 40%. The drug achieves a maximum serum concentration after 1-2 h. T_0,5 is 2-3 hours. Metabolized in the liver, excreted in the urine. Ascorbic acid participates in the biosynthesis of collagen and intercellular substance and acts as an antioxidant. It is necessary in the hydroxylation of adrenal steroids and bile acid biosynthesis. In addition, it participates in the metabolic processes of tyrosine, phenylalanine, folic acid, iron, histamine, noradrenaline, Carnitine, proteins and lipids. Stimulates prostacyclin synthesis, inhibits thrombosan synthesis, inhibits lipid peroxidation, inactivates superoxide free radicals. He is considered to be a modulator of immunity through participation in the production of immunoglobulins. The digestive tract is absorbed in 70-80%, in 25% bound to plasma proteins. The maximum concentration in plasma reaches after 2-3 h. It is excreted by the kidneys in both the initial form and metabolites.

Hypersensitivity to active substances, sympathomimetic amines or any of the excipients. Unstable coronary heart disease. Heart arythmia. High blood pressure. Congenital G-6-PD deficiency and mathemoglobin reductase. Severe hepatic or renal failure. Viral hepatitis. Alcoholic disease. Phenylketonuria (due to the content of aspartame). Simultaneous treatment with MAO inhibitors and up to 2 weeks after discontinuation of their use. Simultaneous treatment with zidovudine. Cane with a narrow angle of filtration. Anatomically narrow viewing angle.

Do not use in children <12 years. Do not use with other drugs containing paracetamol (risk of overdose). The use of the drug by people with liver failure, abusing alcohol and starved poses a risk of liver damage. Carefully used in people with: renal insufficiency, bronchial asthma, hypertension, prostatic hyperplasia, hyperthyroidism, Raynaud's syndrome, diabetes mellitus, coronary heart disease; taking anticoagulants - it is advisable to adjust their dose based on the blood coagulation markers, and if this is not possible, patients taking oral anticoagulants may take the preparation no longer than a few days.Due to the sucrose content of the preparation should not be used in patients with rare inherited disorders associated with fructose intolerance, malabsorption of glucose-galactose, sucrase-isomaltase deficiency. While taking the preparation, you must not drink alcohol because of the risk of toxic liver damage.

Do not use during pregnancy. There are no data on the safety of the medicine during breastfeeding.

The following may occur: allergic reactions (pruritis, urticaria); hypersensitivity reactions up to the symptoms of anaphylactic shock; nausea, vomiting, digestive disorders, epigastric burning, dry mouth; increase in blood pressure, tachycardia, arrhythmias, paleness of coatings; breathing disorders, bronchial asthma attack; urination disorders, renal colic, renal papillary necrosis; anxiety, insomnia; hallucinations, anxiety, nervousness; granulocytopenia, agranulocytosis, thrombocytopenia.

Orally. Adults and adolescents> 12 years: 1 sachet every 4-6 h (maximum 6 sachets daily). The contents of the sachet should be dissolved in a glass of hot water.