Index of drugs

Treatment of influenza and flu-like symptoms with fever and headaches, muscle and bone-joint pain, as well as treatment of symptoms of rhinitis and paranasal sinuses. It can be used in patients in whom the use of NSAIDs and Acetylsalicylic acid derivatives is not recommended.

1 soft capsule contains 250 mg of Paracetamol and 30 mg of pseudoephedrine hydrochloride.

The preparation has analgesic, antipyretic effect, reduces congestion of the mucous membranes of the upper respiratory tract. Paracetamol is antipyretic, probably by inhibiting the synthesis of prostaglandins in the hypothalamus. The analgesic effect is associated with the central action of increasing the pain threshold. It is well absorbed from the digestive tract, the maximum concentration in the blood after oral administration occurs after about 1 hour. It is slightly bound to plasma proteins (20% -50%), T_0,5 is 2-4 h. Paracetamol is virtually entirely (approximately 95%) metabolised in the liver. It is coupled with gucuronic and sulfuric acid to non-toxic, easily excreted compounds. Adults predominate with glucuronic acid and in children with sulfuric acid. The remainder undergoes hydroxylation catalyzed by P450 enzymes and produces the toxic metabolite N-acetyl-p-benzoquinone (NAPQI). If paracetamol is used in therapeutic doses, NAPQI is coupled with mercapturic acid or cysteine. If you take higher doses of Paracetamol, the hepatic glutathione resources may be depleted, causing the toxic metabolite to accumulate in the liver, which may lead to hepatocyte damage and necrosis, as well as acute hepatic failure. The drug is excreted in the urine in the form of metabolites and only in a small amount in the unchanged form. Pseudoephedrine acts on α-adrenergic receptors in the mucous membrane of the upper respiratory tract, causing narrowing of the blood vessels, which reduces nasal congestion and increases its patency. The beginning of its operation appears after 30 minutes. and persisted for at least 4 h. The maximum serum concentration occurs after 2 h. T_0,5 after a single dose is 5-8 h. Metabolism occurs in the liver, partly to the active metabolite - norpseudoephedrine, and excretion through the kidneys (excretion is faster at reduced pH, and slower when urine is alkaline).

Hypersensitivity to the components of the preparation. The use of MAO inhibitors and up to 2 weeks after stopping taking them. Severe liver and kidney problems. G-6-PD deficiency (possible haemolysis). Anemia. Hypertension and ischemic heart disease. Alcoholic disease.

Excessive use of the preparation may cause liver damage, inflammation of the kidneys, methemoglobinemia and non-myeloid anemia. Caution should be exercised in patients with jaundice, starved animals, those taking medications lowering blood pressure, tricyclic antidepressants and other sympathomimetic medicines (mucosal vasodilators, appetite suppressants, amphetamines-like psychostimulants - single-dose effect on blood pressure is recommended patients with diabetes), hyperthyroidism, prostatic hyperplasia, arrhythmia, elevated intraocular pressure, in the elderly. During the treatment, do not use other drugs containing paracetamol and pseudoephedrine (the maximum dose of paracetamol is 4 g / day, the maximum therapeutic dose of pseudoephedrine for children is 30 mg, daily 120 mg, and for adults, respectively 60 mg and 240 mg). Due to the sorbitol content, the preparation should not be used in patients with rare hereditary fructose intolerance. The carteline red contained in the preparation may cause allergic reactions.

It can only be used during pregnancy if the benefit to the mother outweighs the potential risk to the fetus.It is not recommended for women who are breastfeeding despite the slight penetration of both paracetamol and pseudoephedrine into milk.

The following may occur: rash, erythema, pruritus; thrombocytopenia, leukopenia, agranulocytosis; nephrotoxicity (mainly in combination with NSAIDs), urinary retention in men; sleep disorders, hallucinations, restlessness; tachycardia, ventricular arrhythmias, increased pulmonary blood pressure.

Orally. Adults and children> 12 years: 2 capsules every 4-6 h, maximum 8 caps / day. Children aged 6-12: 1 cap. Every 6 hours, maximum 4 caps / day.