Immediate control of cold symptoms, influenza, flu-like symptoms (fever, runny nose, cough, headache, sore throat, muscle and osteoarticular pain).
Composition:
1 tabl powl. contains 325 mg of Paracetamol, 30 mg of pseudoephedrine hydrochloride, 15 mg dextromethorphan hydrobromide.
Action:
It has analgesic and antipyretic effects, antitussive and patency of the nasal passages and the mouths of the paranasal sinuses, reduces the amount of mucous secretion and congestion and swelling of the mucous membrane of the nasal passages. Paracetamol has an analgesic and antipyretic effect, mainly by inhibiting the activity of prostaglandin cyclooxygenase at o.u.n. It is well absorbed from the gastrointestinal tract, the maximum concentration in the blood reaches after 30-60 min, penetrates into body fluids and internal organs, ca. 25% is bound to plasma proteins. T0,5 is 3-4 hours. It is metabolized in the liver, excreted in the urine in the form of glucuronides, sulphates and after conjugation with cysteine. Pseudoephedrine hydrochloride shrinks the blood vessels, reducing congestion of the nasal mucosa. It is excreted in the urine in unchanged form. Dextromethorphan hydrobromide has an inhibitory effect on the cough reflex by directly affecting the cough center in the medulla, thereby reducing the intensity of dry, irritating cough. It is absorbed quickly from the digestive tract. Antitussive effect occurs about 30 minutes after administration and lasts for 5-6 hours. In therapeutic doses, the drug does not inhibit the function of the ciliary bronchial epithelium.
Contraindications:
Hypersensitivity to the components of the preparation. Anemia, severe liver or kidney failure, children under 12 years of age, concomitant therapy with MAO inhibitors (currently or within the last 2 weeks), in patients receiving concomitant medications containing paracetamol, dextrometrofan or pseudoephedrine. Cough with high secretion, bronchial asthma and cough associated with bronchial asthma, severe hypertension, severe ischemic heart disease, cystic fibrosis, pregnancy and breastfeeding.
Precautions:
Use with caution in patients with hepatic and / or renal impairment. During the use of the preparation should not drink alcohol due to an increased risk of toxic liver damage. Do not use other depressive drugs at o.u.n. Use caution if you experience difficulty breathing, if you have emphysema, chronic bronchitis, prostatic hypertrophy, hyperthyroidism, diabetes, hypertension, ischemic heart disease, arterial disease, closed-angle glaucoma, phaeochromocytoma. Caution should be exercised when using the preparation in the elderly, due to the higher probability of nervous system side effects. Caution should be exercised in patients taking sedatives, weakened or immobilized for a long time.
Pregnancy and lactation:
Do not use this medicine during pregnancy unless clearly necessary. It should not be used during breast-feeding.
Side effects:
Cardiac arrhythmia, shortness of breath, rash, pruritus, changes in blood pressure may occur. Liver and bile duct disorders have been observed: from clinically insignificant elevations of liver enzymes to liver damage. Hepatotoxic effects are particularly pronounced in cases of malnutrition, alcoholism and co-morbidities, as well as when taking certain medications. Rarely observed: drowsiness, dizziness, euphoria, excessive sedation, a feeling of emptiness in the head, anxiety, nervousness, irritability, mood disorders, psychomotor agitation, nausea, vomiting, abdominal pain, constipation, allergic reactions. Very rare: agranulocytosis, thrombocytopenia, neutropenia. Some symptoms (eg nausea, vomiting, drowsiness, dizziness, shortness of breath) may be more frequent and more severe in immobilized patients.
Dosage:
Orally. Patients over 12 years of age: 2 tabl.3-4 times a day; up to 8 tabl. per day.
(C)
