Low to moderate pain: headache including migraine, osteoarticular, muscular, neuralgia and pain after surgical and dental procedures. Febrile states. The drug can be used in patients with hypersensitivity to salicylates.
Composition:
1 tabl contains 500 mg of Paracetamol and 65 mg of caffeine.
Action:
A complex drug with analgesic and antipyretic effects. The mechanism of action of paracetamol consists mainly in the selective inhibition of prostaglandin synthesis in o.u.n. It does not affect the blood coagulation process and does not cause damage to the gastric mucosa. It is well absorbed from the gastrointestinal tract, the degree of protein binding varies from 5% to 50% depending on the dose (on average it is 25%). Metabolism occurs mainly in the liver, and excretion occurs mainly in the urine, after conjugation with glucuronic acid or sulfuric acid. A small amount (approximately 5%) of the potentially hepatotoxic intermediate metabolite N-acetyl-p-benzoquinone (NAPQI) is completely conjugated to glutathione and excreted in combination with cysteine or sulfuric acid. If high doses of paracetamol are used, there may be depletion of hepatic glutathione, which causes the accumulation of toxic metabolite in the liver. The biological half-life of paracetamol is 1-3 hours. The drug is excreted mainly in the urine (over 90%). Paracetamol crosses the placenta and into the breast milk of the nursing mother. Caffeine enhances the analgesic effect of paracetamol and stimulates the central nervous system (which removes fatigue). It is well absorbed after oral administration, with proteins binding in 25% -36%. It is metabolised mainly in the liver. T0,5 is 3-7 h. It is excreted in the urine, mainly in the form of metabolites and in 1% -2% in the unchanged form.
Contraindications:
Hypersensitivity to Paracetamol, caffeine or any of the excipients. Severe hepatic or renal failure. Alcoholic disease. Angina pectoris. Hypertension. Heart arythmia. Anxiety syndrome. G-6-PD deficiency. And trimester of pregnancy. Breastfeeding period.
Precautions:
Use in children under 12 years is not recommended. In patients with liver damage, starvation and alcoholism there is a risk of hepatotoxic effects after therapeutic doses. In the event of symptoms of liver or kidney failure, the drug should be immediately discontinued. Do not use alcohol while using the preparation. Caution should be exercised in patients with peptic ulcer disease, renal insufficiency, bronchial asthma, hyperthyroidism, and insomnia. Do not use other preparations containing paracetamol or its combinations with other medicines, as overdose may occur. Excessive amounts of coffee or tea should be avoided during treatment.
Pregnancy and lactation:
Due to the caffeine content, it should not be used during the first trimester of pregnancy and breastfeeding.
Side effects:
Rare: allergic reactions (pruritus, urticaria, rash, erythema), epigastric pain and burning, nausea, vomiting; arrhythmia, headaches, sleep disorders; muscular tremors. Isolated cases: thrombocytopenia, agranulocytosis, pancytopenia. Methemoglobinemia (the presence of methaemoglobin in the blood) may also occur.
Dosage:
Adults. Temporary: 1-2 tabl. 3-4 times a day. Do not take more than 8 tables. daily (4 g of paracetamol). In chronic pain: 1 tabl. every 4-6 h. The tablets should be taken at intervals of not less than 4 hours, after eating, abundantly washed down.
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