Index of drugs

Pain of various origins of low and medium severity (headache, teeth, muscles, joints, menstrual cramps, neuralgia and others). Fever in colds and flu-like conditions.

5 ml of syrup contains 120 mg of paracetamol.

A drug with analgesic and antipyretic effect. As a result of inhibition of arachidonic acid cyclooxygenase, it prevents the formation of prostaglandins at o.u.n. The effect of this interaction is a decrease in susceptibility to such mediators as kinins and serotonin, which is indicated by an increase in the pain threshold. The reduction in the concentration of prostaglandins in the hypothalamus causes antipyretic effects. The analgesic effect of Paracetamol is similar to that of NSAIDs, however, paracetamol does not inhibit peripheral prostaglandin synthesis. Therefore, it does not have an anti-inflammatory effect and does not induce side effects typical of NSAIDs. Paracetamol does not affect platelet aggregation. The drug is absorbed quickly after oral administration, the bioavailability is 88%. The highest bioavailability (over 90%) is observed after administration of paracetamol in syrup. The main route of elimination of the drug is its biotransformation in the liver. Only a small part of it (2-4%) is excreted unchanged by the kidneys. The main metabolite (approximately 90%) in adults is the combination with glucuronic acid and in children with sulfuric acid. As a result, the hepatotoxic intermediate metabolite N-acetyl p-benzoquinone (about 5%) is bound to hepatic glutathione, and then, in combination with cysteine ​​and mercapturic acid, it is excreted in the urine. Approx. 85-90% of the dose is excreted in the urine within 24 hours_0,5 is 1-3 hours. Food retards absorption. A small amount of the drug is excreted in the bile. The binding of the drug to proteins is up to 20-30%. The drug passes into the brain, through the placenta, it passes into the milk of nursing mothers, where it is in a concentration close to the plasma concentration.

Hypersensitivity to paracetamol or other ingredients of the preparation. Severe hepatic or renal failure. The use of MAO inhibitors and up to 2 weeks after they have been discontinued. Congenital G-6-PD deficiency and methemoglobin reductase.

Do not take other paracetamol-containing medicines while taking the product. Alcohol increases the toxic effects of paracetamol - alcohol must not be taken while taking the preparation. The use of the preparation by people with liver dysfunction, alcohol abuse and starved poses a risk of liver damage. Use cautiously in people with liver and kidney failure and bronchial asthma. The preparation contains propyl parahydroxybenzoate, which may cause allergic reactions (possible late-type reactions). Due to the sorbitol content of the preparation should not be used in patients with rare hereditary fructose intolerance. The preparation may have a slight laxative effect.

Paracetamol crosses the placenta. There was no adverse effect on the fetus of paracetamol at the recommended doses. The drug is excreted in milk in amounts of no clinical significance. The product can be used during pregnancy and breastfeeding in case of extreme necessity.

The most important side effect is acute liver damage, usually due to an overdose. The following may occur: nausea, vomiting, digestive disorders, allergic reactions (urticaria, erythema, rash, pruritus, pigmented purpura, anaphylactic shock), isolated cases of hematological disorders (methaemoglobinaemia, thrombocytopenia, agranulocytosis).

Orally. Adults: 0.3-1 g every 4 h up to 4 times a day, maximum 4 g a day. In children, the recommended dose is 10-15 mg / kg m.c. every 4 hours to 4 times a day. For example: children from 6 years to 12 years: 240-480 mg (10-20 ml); children from 2 years to 6 years: 120-240 mg (5-10 ml). In children up to 2 years of age, the preparation should only be prescribed by a doctor. The maximum daily dose in children is 65 mg / kg. The product should not be used for more than 10 days in adults and 3 days in children without a doctor's recommendation.