Headaches, throats, migraines, toothache, bone, joint and muscle pain, and dysmenorrhea. Fever in colds and flu-like conditions.
Composition:
1 tabl contains 500 mg of Paracetamol in combination with povidone.
Action:
Analgesic and antipyretic. Paracetamol inhibits the biosynthesis of prostaglandins by inhibiting the activity of arachidonic acid cyclooxygenase at o.u.n. It does not affect platelet aggregation. Paracetamol is rapidly and almost completely absorbed from the gastrointestinal tract and is evenly distributed to body fluids. The rate of absorption decreases when taking paracetamol with a meal. At therapeutic doses, paracetamol binds to plasma proteins to a small extent. It is metabolised in the liver and almost completely excreted in the urine in the form of a conjugated - glucuronide and sulfate. Less than 5% of the paracetamol dose is excreted unchanged. T0,5 ranges from 1-4 h. In severe hepatic insufficiency0,5 paracetamol may be prolonged. The clinical significance of T extension0,5 paracetamol is not known in patients with liver disease. More than 90% of the therapeutic dose of paracetamol is usually excreted in the urine as metabolites within 24 hours. In patients with chronic renal failure, the excretion of polar metabolites is limited, which can lead to their accumulation.
Contraindications:
Hypersensitivity to paracetamol or to any of the excipients. Alcoholic disease. Severe hepatic or renal failure.
Precautions:
The drug is not recommended for use in children under 6 years. Caution should be exercised in patients with hepatic and / or renal failure as well as in patients deficient in glucose-6-phosphate dehydrogenase and methemoglobin reductase. During the use of the drug, do not take other preparations containing paracetamol due to the risk of overdose. During treatment with Paracetamol, you should not drink alcohol due to the increased risk of toxic liver damage. There is a special risk of liver damage in people who are starved and regularly consuming alcohol.
Pregnancy and lactation:
Paracetamol should be used during pregnancy and during breastfeeding in case of extreme necessity. Epidemiological studies conducted in pregnant women did not show any adverse effects of paracetamol administered at the recommended doses. Paracetamol is excreted in breast milk in amounts that are not clinically relevant. Available published data do not contain contraindications to breastfeeding while taking the drug.
Side effects:
Rare: allergic reactions, eg skin rash, epigastric pain, nausea, vomiting, pancreatitis, liver damage, hepatomegaly, jaundice. Very rare: thrombocytopenia, methemoglobinemia, agranulocytosis. After overdose - impaired liver and kidney function.
Dosage:
Orally. Adults and adolescents> 12 years: 1 g once, if necessary, the dose can be repeated every 4 hours, up to 4 times a day; the maximum daily dose of paracetamol is 4 g. Children aged 6-12 years: 250-500 mg, if necessary, the dose can be repeated every 4 hours, up to 4 times a day. The drug should not be used for more than 3 days without the doctor's recommendation. In patients with chronic renal failure, it is recommended to prolong the intervals between successive doses of paracetamol.
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