Pains of various origins, including headaches (including migraines), menses, joints, muscles, after injuries, after surgical and dental procedures; in cold and flu diseases.
Composition:
1 tabl contains 500 mg of paracetamol.
Action:
The drug with analgesic and antipyretic effect, mainly by inhibiting the activity of prostaglandin cyclooxygenase at o.u.n. Well absorbed from the gastrointestinal tract, the maximum concentration in the blood reaches after about 30-60 min, penetrates into body fluids and internal organs, in about 25% bound to plasma proteins. T0,5 is 3-4 hours. It is metabolized in the liver, induces microsomal enzymes there; excreted in the urine in the form of glucuronides and sulphates and after conjugation with cysteine. In patients with renal failure, conjugated Paracetamol accumulates in the blood. After high doses, N-acetyl-p-benzoquinone in the body is probably responsible for causing liver damage.
Contraindications:
Hypersensitivity to paracetamol or to the rest of the preparation. Severe renal or hepatic failure. Alcoholic disease.
Precautions:
Because of the risk of overdose, check that other medicines do not contain paracetamol. Special care should be taken in patients with impaired liver or kidney function. The risk of liver damage is particularly high in regular drinkers. Long-term treatment (adults over 10 days) should only be carried out under medical supervision. Due to the sorbitol content, the preparation should not be used for congenital fructose intolerance.
Pregnancy and lactation:
During pregnancy and breastfeeding, use only if absolutely necessary.
Side effects:
Uncommon: vomiting, diarrhea. Rare: hives, erythema, dermatitis. Very rare: thrombocytopenia, leukopenia, agranulocytosis, hepatomegaly. Paracetamol used in high doses or long-term may impair the function of the liver and / or kidneys.
Dosage:
Orally. Adults and youth over 12 years: 1 or 2 tabl. every 4 hours, up to 4 g a day. The maximum daily dose: for short-term use (up to 3 days) - 8 tabl. in divided doses; when used for a long time (up to 10 days) - 5 tabl. in divided doses. The interval between consecutive doses should be at least 4 hours.
(C)
