Index of drugs

Symptoms associated with menstruation: headache, backache, muscle aches and pains, edema, bloating, fatigue.

1 tabl powl. contains 500 mg of Paracetamol, 60 mg of Caffeine and 15 mg of mepyramine.

The Paracetamol contained in the preparation has analgesic and antipyretic effect, mainly by inhibiting the activity of prostaglandin cyclooxygenase at o.u.n. Well absorbed from the gastrointestinal tract, the maximum concentration in the blood reaches after about 30-60 min, penetrates into body fluids and internal organs, in about 25% bound to plasma proteins. T_0,5 is 2-3 hours. It is metabolized in the liver, induces microsomal enzymes there; excreted in the urine in the form of glucuronides, sulphates and after coupling with cysteine. In patients with renal failure, conjugated paracetamol accumulates in the blood. After high doses, N-acetyl-p-benzoquinone in the body is probably responsible for causing liver damage. The caffeine contained in the preparation is well absorbed from the gastrointestinal tract, metabolized in the liver, metabolites excreted in the urine. It works by inhibiting the phosphodiesterase activity, increasing the amount of cAMP in the cells. It stimulates vegetative centers: respiratory, vasomotor and vagus nerve. The stimulation of the respiratory center increases the frequency and increases the volume of breaths. The stimulation of the vasomotor center, the cardiac conduction system and the reduction of muscle tone in the blood vessels results in the acceleration of cardiac function and a slight increase in blood pressure. It works analeptically (removes the feeling of tiredness, drowsiness, improves the efficiency of thinking); stimulates the secretion of gastric juice, it works diuretic. The preparation used the antipyretic and analgesic effects of paracetamol, a beneficial effect of caffeine on pain and the improvement of well-being. Mepyramine is an antihistamine with a weak sedative effect, in allergic diseases used in doses several times higher than the one used in the composition of the preparation.

Hypersensitivity to the components of the preparation. Severe hepatic or renal failure, alcoholism; congenital G-6-PD deficiency and methemoglobin reductase, anemia; children under 12 years. Caution should be exercised in patients with bronchial asthma allergic to Acetylsalicylic acid, in liver dysfunction (resulting from alcoholism, hepatitis or in fasted patients). Due to the caffeine content, do not use in children; cautiously in peptic ulcer of the stomach and duodenum, arterial hypertension, angina pectoris. Use with caution in pregnancy (especially in the first trimester).

During the treatment, dyspeptic symptoms may occur; allergic reactions in the form of skin lesions (urticaria, erythema, dermatitis, purpura pigmentosa). There are single descriptions of changes in the morphological picture of blood after paracetamol: thrombocytopenia (with symptoms of thrombocytopenic purpura), agranulocytosis, methemoglobinemia. When used in high doses or long-term, it may impair the function of the liver and / or kidneys. Due to the caffeine content, with long-term abuse may occur: irritability, anxiety, tachycardia, muscle tremors, symptoms of anxiety neurosis, sleep disorders, insomnia.

Orally. Adults and children over 12 years of age: 2 tablets every 6 hours, no more than 8 tabl. per day.