the product in the database has an inactive status
indications:
Relief of cold and flu symptoms with cough, runny nose, swelling of the nasal mucosa and sinuses, general breakdown, sneezing, sore throat and sore throat, headache, fever.
Composition:
1 elastic capsule contains 250 mg of Paracetamol, 30 mg of pseudoephedrine hydrochloride, 10 mg dextromethorphan hydrobromide and 6.25 mg of doxylamine succinate.
Action:
The drug against the symptoms of colds and flu with the combined action of ingredients. Paracetamol has an analgesic and antipyretic effect, mainly by inhibiting the activity of prostaglandin cyclooxygenase at o.u.n. Well absorbed from the gastrointestinal tract, the maximum concentration in the blood reaches after about 60 min, penetrates into body fluids and internal organs, in about 25% bound to plasma proteins. T0,5 it is 3-4 hours. It is metabolized in the liver, excreted in the urine in the form of glucuronides, sulphates and in the form conjugated with cysteine. Pseudoephedrine hydrochloride shrinks blood vessels, reduces congestion of the nasal mucosa, making breathing easier. Dextromethorphan hydrobromide exhibits a central antitussive effect, lasting 5-6 h after a single dose. It is well absorbed from the gastrointestinal tract, it is partially metabolized in the liver, excreted in the urine in an unchanged state and in the form of metabolites; T0,5 is 5-8 h. Doxylamine succinate is an antihistamine; it relieves symptoms of rhinitis (eg runny nose, sneezing).
Contraindications:
Hypersensitivity to any of the ingredients. Concomitant treatment with MAO inhibitors and for 2 weeks after discontinuation or zidovudine (AZT). Congenital G-6-PD deficiency. Severe hepatic or renal failure. Do not use in children.
Precautions:
Caution in patients with upper respiratory tract disorders (emphysema, chronic bronchitis), in asthma and conditions with mucosal secretion, in persistent or chronic cough in smokers, in patients with glaucoma, prostatic hyperplasia, hypertension, heart disease , overactive thyroid gland, diabetes. In patients with liver failure (eg associated with alcohol abuse or jaundice), renal insufficiency and Gilbert's syndrome, the drug should be used with caution.
Pregnancy and lactation:
During pregnancy, use only in cases where the benefit for the mother outweighs the potential risk to the fetus. Do not use during breastfeeding (the components of the drug are excreted in breast milk).
Side effects:
In rare cases, headache, drowsiness, stomach upset, nausea, vomiting, dry mouth, increase in blood pressure, arrhythmia, excitability, restlessness, insomnia have been reported. A paradoxical psychomotor agitation is possible, especially in children. Due to the content of sympathomimetic, anxiety, tremors, hallucinations, epileptic seizures, difficulty in breathing, and difficult urination may occur. If you are hypersensitive to NSAIDs - an asthma attack. Occasionally: cutaneous allergic reactions, erythema, dermatitis. Exceptionally - thrombocytopenia, leukopenia, pancytopenia. Hypersensitivity reactions have been reported: angioneurotic edema, impaired breathing, respiratory failure, increased sweating, hypotension, shock.
Dosage:
Orally. Adults: 2 capsules once a day, in the evening before bedtime. Do not increase the recommended dose. The capsules should be swallowed with a small amount of water. Do not use for more than 7 days.
(C)
