Local treatment of fungal infections of the skin, such as: skin mycosis and skin folds, for example, mycosis of the smooth skin, inguinal mycosis (often itchy, irregular, pink-red, slightly raised spots, on the circumference of which may appear clumps and bubbles); athlete's tinea (hand fungus, athlete's foot), most often showing excessive flaking and cracking of the skin, with pruritus and burning; skin infection caused by yeasts, manifesting as itchy, red, often exfoliating spots in which bubbles can be formed; dandruff versicolor (mottled color changes from white to brown, irregular, with a peeling surface, occurring mainly on the skin of the trunk, these changes do not change color under the influence of the sun).
Composition:
1 g of cream contains 10 mg of naphtyphine hydrochloride. The cream contains benzyl alcohol.
Action:
Antifungal medicine for topical application to the skin. Naphtyphine works antifungal primarily for dermatophytes (Trichophyton spp., Microsporum spp., Epidermophyton spp.), yeasts (Candida spp.), molds (Aspergillus spp.) andSporothrix Schenkii.In vitro naphtyphine fungicide on dermatophytes and moldsAspergillus spp. Yeast fungicide or fungistatic, depending on the strain. Naphthyfine also has a bactericidal effect on Gram-positive and Gram-negative bacteria coexisting in the fungal outbreaks. It also has anti-inflammatory effects. After topical administration, the naphtyphine penetrates well through the stratum corneum and occurs in individual layers of the skin at a concentration that ensures antifungal activity. After application of 1% cream to healthy skin, approximately 3-6% of the dose penetrates the circulation. The concentration of naphtyphine sufficient to inhibit the growth of dermatophytes is maintained in the skin for approx. 24 h. The absorbed drug and its metabolites are excreted in urine and faeces.
Contraindications:
Hypersensitivity to naphthepine or any of the excipients.
Precautions:
Avoid contact of the cream with eyes, mouths, mucous membranes and wounds. If signs of skin irritation occur, discontinue use. The drug should not be used in children, due to the lack of data on the safety of use in this group of patients. The cream contains cetyl alcohol and stearyl alcohol, which can cause local skin reactions (eg contact dermatitis).
Pregnancy and lactation:
The drug should not be used during pregnancy or breastfeeding.
Side effects:
Not known: redness, dryness and burning sensation. These effects are transient and it is usually not necessary to discontinue the medicine.
Dosage:
Outwardly. Adults, once a day, apply a layer of cream to the washed and dried diseased skin and its surroundings. The cream should be used for at least 7 days. After the disappearance of clinical symptoms, treatment should be continued for 2 weeks. If no improvement occurs after 7 days or the patient feels worse, the patient should consult a physician.
(C)
