1 g of the nail polish contains 80 mg of ciclopirox.
Action:
Antifungal medicine, a derivative of pyridinone. Works fungicidal onTrichophyton rubrum, T. mentagrophytes, Epidermophyton floccosum, Microsporum canis andCandida albicans. Ciclopirox passes through the nail plate; the therapeutic effect occurs after 48 hours after application. The average level of absorption of ciclopirox from lacquer (8% concentration) after application to the nail plate of all 20 fingers and the adjacent skin fragment 5 mm wide once a day for 6 months in patients with onychomycosis is <5% of the applied dose. One month after stopping treatment, the plasma levels of ciclopirox are below the detection level. Ciclopirox passes through the nail plate to a depth of approx. 0.4 mm and its concentration decreases with depth, with proteins binding in about 94-97%. Ciclopirox and its metabolites are rapidly excreted by the kidneys.
Contraindications:
Hypersensitivity to the active substance or any of the excipients. Children (insufficient data).
Precautions:
Avoid contact of the preparation with eyes and mucous membranes. Apply only on nails.
Pregnancy and lactation:
Do not use the product during pregnancy and breastfeeding if it is not absolutely necessary.
Side effects:
In a few patients irritation was observed (burning, itching, erythema, swelling, redness and flaking) after the lacquer contact with the skin surrounding the nail.
Dosage:
Outwardly. Adults. Apply a thin layer of lacquer with a brush to the nail plate and let it dry. Use every other day in the first month of treatment; in the second month of treatment, the use can be limited to twice per week; from the third month of treatment, apply once a week. During the entire treatment period, wash the entire nail polish once a week using a nail polish remover. In the event of damage or clash of the lacquer layer, it is sufficient to coat the exposed areas during treatment. The maximum duration of use is 6 months.
(C)
