In adults and children aged 6 years and older: Cetirizine is indicated for the relief of nasal and eye symptoms associated with seasonal and chronic allergic rhinitis and to relieving symptoms of chronic idiopathic urticaria.
Composition:
1 tabl powl. contains 10 mg of cetirizine dihydrochloride. The preparation contains lactose.
Action:
Cetirizine, a metabolite of hydroxyzine, is a potent and selective antagonist of peripheral histamine H-receptors1. In addition, it has antiallergic activity, inhibits the influx of cells in the late phase of the inflammatory reaction, eosinophils, to the skin and conjunctiva. Cetirizine is well absorbed from the gastrointestinal tract; food prolongs absorption, but does not affect the bioavailability of the drug. It binds approximately 93% to plasma proteins. It is slightly metabolised in the liver and excreted mainly in unchanged form in the urine. T0,5 in the blood is about 10 hours in adults, in children 2-6 years 5 hours.
Contraindications:
Hypersensitivity to the active substance, any of the excipients, hydroxyzine or piperazine derivatives. In patients with severe renal impairment with a creatinine clearance less than 10 ml / min. Patients with rare hereditary galactose intolerance, lactase deficiency (Lapp type) or malabsorption of galactose Glucose should not take this medicinal product.
Precautions:
Caution is advised when using in patients with epilepsy and in patients at risk of convulsions. The use of coated tablets is not recommended in children under the age of 6 years because this pharmaceutical form does not allow for a suitable dose adjustment.
Pregnancy and lactation:
Caution should be exercised when using the preparation in pregnant and breast-feeding women, as cetirizine is excreted in human milk.
Side effects:
Drowsiness, fatigue, dizziness, agitation, increased liver enzymes and bilirubin in the blood, rhinitis, pharyngitis, diarrhea, nausea, and abdominal pain have been reported. In isolated cases - difficulty urinating, disturbed eye accommodation, dry mouth. Uncommon: paresthesia, pruritus, rash, weakness, malaise; rare: hypersensitivity reactions, aggression, confusion, depression, hallucinations, insomnia, convulsions, movement disorders, tachycardia, urticaria, edema, weight gain; very rare: thrombocytopenia, anaphylactic shock, tics, dysgeusia, dyskinesia, dystonia, syncope, tremor, angioedema, drug eruption, accommodation disorder, blurred vision, eyeball rotation, painful or difficult urination, involuntary urination.
Dosage:
Children from 6 years to 12 years old: 5 mg twice daily (half a tablet twice a day).Adults and adolescents over 12 years of age: 10 mg (1 tablet) once a day. In renal insufficiency with a creatinine clearance of 30-49 ml / min 5 mg administered once a day; <30 ml / min - 5 mg every 48 hours. No dose adjustment is necessary in patients with impaired hepatic function or in the elderly if normal function is normal. In children with renal insufficiency, the dose should be determined based on creatinine clearance, age and body weight. The tablets should be swallowed with a glass of liquid.
(C)
