Relief of symptoms associated with allergic rhinitis and urticaria. Table. 5 mg for use> 12 years; Table. 2.5 mg> 6 years.
Composition:
1 tabl orally disintegrating contains 2.5 mg or 5 mg desloratadine; Table. they contain aspartame.
Action:
Desloratadine is a sedative, long-acting histamine antagonist with selective antagonistic activity towards peripheral H-receptors1. Antiallergic properties of desloratadine include inhibiting the release of cytokines inducing an inflammatory response (i.e., IL-4, IL-6, IL-8 and IL-13) from human mast cells and basophils, as well as inhibiting the expression of P-selectin on the surface of endothelial cells. In patients with allergic rhinitis, desloratadine is effective in relieving symptoms such as sneezing, pruritus, nasal discharge, as well as itching, tearing and redness of the eyes and pruritis. In patients with urticaria, it reduces the number and size of urticarial lesions and soothes pruritus. Desloratadine does not easily penetrate to o.u.n., so that it practically does not exert a calming effect, does not cause drowsiness or does not affect psychomotor activity. Desloratadine is rapidly absorbed from the gastrointestinal tract (about 30 min), reaching Cmax after about 3 h. Plasma protein binding is 83-87%. T0,5 is 27 hours.
Contraindications:
Hypersensitivity to the active substance or to any of the excipients or loratadine.
Precautions:
Use with caution in patients with severe renal impairment. The efficacy and safety of desloratadine in the form of 5 mg orodispersible in children <12 years of age; in the form of tabl. orally disintegrating 2.5 mg - in children <6 years of age. Due to the content of aspartame, the drug may be harmful for people with phenylketonuria.
Pregnancy and lactation:
The safety of the medicine during pregnancy has not been established, therefore the use of desloratadine during pregnancy is not recommended. Desloratadine is excreted in breast milk, therefore it is not recommended during breast-feeding.
Side effects:
Common: tiredness, dryness of the oral mucosa, headache. Very rare: hallucinations, dizziness, drowsiness, insomnia, psychomotor agitation, convulsions, tachycardia, palpitations, abdominal pain, nausea, vomiting, indigestion, diarrhea, increased liver enzymes, increased bilirubin in the blood, hepatitis, muscle pain, hypersensitivity reactions (including anaphylaxis, angioneurotic edema, dyspnoea, pruritus, rash, urticaria). Not known: photosensitivity.
Dosage:
Orally. Adults and adolescents ≥12 years: 5 mg once a day; children 6-11 years: 2.5 mg once a day. In periodic allergic rhinitis (symptoms occur less than 4 days in a week or less than 4 weeks), treatment should be discontinued after the symptoms have resolved and resumed when they recur. In chronic allergic rhinitis (symptoms occur for 4 days in a week or more and for more than 4 weeks) you can continue treatment during the period of exposure to the allergen. Treatment of allergic rhinitis and urticaria with desloratadine without consultation with a physician should last no longer than 10 days.Way of giving. The drug can be taken regardless of meals. Table. submissive. the verdict in oral language is placed in the oral cavity, where it undergoes immediate disintegration; no water or other liquid is needed to swallow the dose; The dose should be taken immediately after opening the blister. Tablets do not crumble.
(C)
