Treatment of symptoms of perennial and seasonal allergic rhinitis. Treatment of symptoms of chronic idiopathic urticaria.
Composition:
1 tabl contains 10 mg of loratadine. The preparation contains lactose.
Action:
An antihistamine, a selective antagonist of peripheral H-receptors1. Most people do not show clinically significant sedative or anticholinergic effects at the recommended doses. loratadine is quickly absorbed from the gastrointestinal tract. Has a first-pass effect in the liver, is extensively metabolised mainly with the participation of CYP3A4 and CYP2D6 isoenzymes, among others to the active metabolite of desloratadine. Loratadine binds to plasma proteins in 97-99% and desloratadine in 73-76%. Medium T0,5 is 8.4 hours for loratadine and 28 hours for desloratadine. The drug is excreted in the urine and faeces, mainly in the form of conjugated metabolites. Medium T0,5 loratadine is 8.4 h, desloratadine 28 h.
Contraindications:
Hypersensitivity to loratadine or any of the ingredients. Pregnancy and breastfeeding.
Precautions:
The efficacy and safety of use in children under 2 years has not been established. Use with caution in patients with severe hepatic impairment. The preparation contains lactose - do not use in patients with rare hereditary galactose intolerance, lactase deficiency (Lapp type) or malabsorption of glucose-galactose.
Pregnancy and lactation:
The use of the preparation during pregnancy and breast-feeding is contraindicated.
Side effects:
Most often observed: drowsiness, headache, insomnia, increased appetite. Very rare: anaphylactic reaction, dizziness, palpitation, tachycardia, nausea, dry mouth, gastritis, abnormal liver function, rash, alopecia, fatigue.
Dosage:
Orally. Adults and children over 12 years: 10 mg once a day. Children 2-12 years old: mc. > 30 kg: 10 mg once a day; mc <30 kg: 5 mg once a day. The product is intended for children who are able to swallow a tablet. In children from 2 to 6 years, loratadine in the form of a syrup is recommended. In patients with hepatic impairment, the initial dose should be reduced: adults and children with a fat body weight of> 30 kg: 10 mg every other day, children at birth. ≤ 30 kg: 5 mg every other day. There is no need to change the dosage in the elderly and with renal insufficiency.
(C)
