Treatment of chronic allergic rhinitis. Treatment of seasonal allergic rhinitis. Treatment of allergic conjunctivitis. Treatment of chronic idiopathic (idiopathic) urticaria.
Composition:
1 tabl powl. contains 10 mg of Cetirizine dihydrochloride; the preparation contains lactose.
Action:
Antihistamine - a strong and selective antagonist of peripheral histamine H receptors1. It does not have anticholinergic or antiserotonin activity. It inhibits both the early phase of the allergic reaction (depending on histamine) and the late phase, because it inhibits the migration of cells and the release of mediators of the inflammatory process. Cetirizine quickly and almost completely absorbed from the gastrointestinal tract, reaching a maximum concentration in the blood after about 1 hour. Food does not reduce the rate of absorption, but reduces its rate. Cetirizine is 93% bound to plasma proteins. It is slightly metabolised in the liver. It is mainly excreted in the urine (70%), mainly in the unchanged form and partly in the faeces (10%). T0,5 in the blood is 8.3 hours in adults
Contraindications:
Hypersensitivity to Cetirizine, hydroxyzine, piperazine derivatives or other components of the preparation. Severe renal failure (creatinine clearance <10 ml / min).
Precautions:
Use with caution in patients with impaired renal and hepatic function. Due to the lactose content, the preparation should not be used in patients with rare hereditary galactose intolerance, Lapp lactase deficiency or malabsorption of glucose-galactose.
Pregnancy and lactation:
Animal studies do not indicate a harmful effect of cetirizine on pregnancy, embryonal / fetal development, parturition or postnatal development. Caution should be exercised when recommending cetirizine to pregnant women. It should not be used in women who are breastfeeding because cetirizine is excreted in human milk.
Side effects:
At a frequency of 1% or more, fatigue may occur; pain and dizziness; abdominal pain, dryness of the oral mucosa, nausea; somnolence; pharyngitis. With a frequency of 1% or more in children from 6 months to 12 years of age, you may experience diarrhea, drowsiness, inflammation of the nose, fatigue. In individual cases, thrombocytopenia, anaphylactic shock, hypersensitivity reactions, aggressive behavior, agitation, confusion, depression, hallucinations, insomnia, tics may occur; convulsions, dysgeusia, dyskinesia, dystonia, paresthesia, syncope, tremor; accommodation disorders, blurred vision, eye movement, tachycardia, diarrhea, abnormal liver function (increased aminotransfreaze, alkaline phosphatase, GGT, increased bilirubin), angioedema, pruritus, rash, urticaria, drug eruption, painful or difficult urination, involuntary urination, weakness, malaise, edema, weight gain, dryness of the oral mucosa.
Dosage:
Orally. Adults and children> 6 years: 5-10 mg once a day. In patients with hepatic impairment and in the elderly, no dosage adjustment is necessary. In patients with renal insufficiency, the dosage depends on the creatinine clearance - CCr = 50-79 ml / min: 10 mg once a day; CCr = 30-49 ml / min: 5 mg once a day; CCr <30 ml / min: 5 mg every other day; CCr <10 ml / min: do not use. In children with renal impairment, the dose should be determined individually based on the creatinine clearance and body weight of the patient.
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