1 tabl contains 1 mg of clemastine in the form of fumarate; Table. contain lactose. 10 ml of syrup contains 1 mg of clemastine in the form of fumarate; the syrup contains ethanol and sorbitol.
Action:
Antihistamine, a competitive antagonist of H-receptors1. It inhibits the histamine extension and the increase in capillary permeability and contraction of the smooth muscle of the blood vessels, gastrointestinal tract and respiratory tract. It acts anti-pruritus, relieves swelling and urticaria and symptoms of allergic rhinitis. It also has a cholinolytic effect and inhibits the activity o.u.n. Klemastyna is quickly and almost completely absorbed from the gastrointestinal tract. It is metabolized in the liver and excreted in the urine, mainly in the form of metabolites. The onset of action occurs after about 2 hours and lasts for 12-24 hours.
Contraindications:
Hypersensitivity to klemastine, other drugs with a similar chemical structure (e.g., chlorpheniramine, diphenhydramine) or to any of the excipients of the preparation. Do not use during treatment with MAO inhibitors. Do not use in children in 1 year.
Precautions:
Particularly cautiously use in patients with narrow-angle glaucoma, with increased intraocular pressure, with pyloric stenosis, peptic ulcer hampering intestinal transit, symptomatic prostatic hyperplasia and episodes of urinary retention for other reasons (eg obstruction of the bladder neck), bronchial asthma, hyperactivity thyroid gland, cardiovascular disease, hypertension, porphyria, as well as elderly patients (a dose reduction is recommended). Due to the alcohol content, syrup should be used with caution in patients at high risk (with liver disease, epilepsy, alcoholism and children). Due to the sorbitol content, syrup should not be used in patients with fructose intolerance. In addition, the syrup contains p-hydroxybenzoates, which can cause allergic reactions (possible late-type reactions) and propylene glycol, which can cause symptoms as if consumed with alcohol. The tablets contain lactose - they should not be used in patients with rare hereditary galactose intolerance, Lapp lactase deficiency or malabsorption of glucose-galactose. Table. do not use in children <6 years.
Pregnancy and lactation:
Use only in case of extreme necessity. Do not use during breast-feeding.
Side effects:
Most often, sedation, drowsiness, coordination disorders, dizziness, heartburn, nausea, vomiting, abdominal pain, diarrhea, constipation, increased secretion of respiratory secretions were observed. In addition, there was fatigue, confusion, anxiety, excessive agitation (especially in children), weakness, headache and dizziness, tremor, insomnia, blurred vision, tinnitus, seizures, lack of appetite, dry mouth, tightness in the cage thoracic, wheezing, dry nose and throat, nasal congestion, hypotonia, arrhythmias, thrombocytopenia, agranulocytosis, haemolytic anemia, urinary retention, urinary retention, urticaria, skin rash, sweating, chills, hypersensitivity to light .
Dosage:
Orally. Adults and children> 12 years: 1 mg (1 table or 10 ml of syrup) 2 times a day in the morning and in the evening; if necessary, the dose can be increased to 3-4 mg a day. Children 6-12 years: 0.5-1 mg (1 / 2-1 table or 5-10 ml of syrup) 2 times a day, in the morning and in the evening; 3-6 years: 0.5 mg (5 ml of syrup) 2 times a day, in the morning and in the evening; 1-3 years: 0.25-0.5 mg (2.5-5 ml of syrup) 2 times a day, in the morning and in the evening.
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