Relief of symptoms associated with: allergic rhinitis, urticaria.
Composition:
1 tabl powl. contains 5 mg desloratadine. Table. powl. they contain isomalt. 1 ml oral solution contains 0.5 mg desloratadine. The solution contains sorbitol.
Action:
An antihistamine blocking selective peripheral H-receptors1, the active metabolite of loratadine. Long-term inhibits the release (from mast cells and basophils) of cytokines inducing inflammation and the expression of the adhesive P-selectin molecule on the surface of endothelial cells. In patients with seasonal allergic rhinitis, desloratadine effectively relieves symptoms such as sneezing, itching and discharge from the nose, tearing and redness of the eyes and itching of the palate, while in patients with urticaria reduces the number and size of urticaria changes and soothes pruritus. It practically does not penetrate to o.u.n., thanks to which it does not exert a calming effect, does not cause drowsiness or does not affect psychomotor activity. Desloratadine is rapidly absorbed from the gastrointestinal tract (approximately 30 min), reaching a peak in the blood after approximately 3 h. The drug is maintained for 24 h. Plasma protein binding is 83-87%. T0,5 in the blood is 27 hours.
Contraindications:
Hypersensitivity to the active substance, to any of the excipients or to loratadine.
Precautions:
The safety and efficacy of oral solution in infants up to 1 year of age have not been established, in children under 12 years. There is insufficient data on the effectiveness of tabling. and oral solution in adolescents from 12 to 17 years of age. Use with caution in patients with severe renal impairment. The oral solution contains sorbitol - should not be used in patients with fructose intolerance, impaired glucose-galactose absorption or sucrase-isomaltase deficiency; Table. should not be used in patients with fructose intolerance.
Pregnancy and lactation:
The safety of desloratadine in pregnancy has not been established, and the use of the preparation in pregnant women is not recommended. Use during breastfeeding is not recommended.
Side effects:
The most common symptoms were: tiredness, dry mouth, headache. Very rare: hallucinations, dizziness, drowsiness, insomnia, psychomotor agitation, convulsions, tachycardia, palpitations, abdominal pain, nausea, vomiting, indigestion, diarrhea, increased liver enzymes, increased bilirubin in the blood, hepatitis, muscle pain, hypersensitivity reactions (including anaphylaxis, angioneurotic edema, dyspnoea, pruritus, rash, urticaria).
Dosage:
Orally. Adults and adolescents from 12 years: 5 mg once a day (1 table of 5 mg or 10 ml of oral solution). Children from 1 to 5 years of age: 1.25 mg (2.5 ml of oral solution) once a day; 6-11 years: 2.5 mg (5 ml oral solution) once a day. The drug can be taken regardless of meals. Treatment should be discontinued after symptoms have resolved and resumed at the time they recur. In chronic allergic rhinitis, treatment may be continued during exposure to the allergen.
(C)
