Table. 120 mg: relief of symptoms of seasonal, allergic rhinitis. Table. 180 mg: relief of symptoms of chronic idiopathic urticaria.
Composition:
1 tabl powl. contains 120 mg or 180 mg of fexofenadine hydrochloride (equivalent to 112 mg or 168 mg of fexofenadine).
Action:
An antihistamine, an H receptor antagonist1. Fexofenadine is the pharmacologically active metabolite of terfenadine. It does not have sedative effects or significant changes in the QT intervalc in the ECG picture. Rapidly absorbed after oral administration. Maximum plasma concentration occurs after 1-3 h. Plasma protein binding is 60-70%. The drug is metabolised only to a limited extent. It is excreted mainly in the bile, up to 10% of the administered dose is excreted in the urine in unchanged form.
Contraindications:
Hypersensitivity to the active substance or any of the excipients.
Precautions:
Use with caution in elderly patients, patients with impaired renal or hepatic function, as the use data in this group is limited. Patients with an active history of cardiovascular disease should be warned that the use of antihistamines may cause side effects such as tachycardia and arrhythmias. Use in children under 12 years is not recommended (no data on safety and efficacy).
Pregnancy and lactation:
There are no data on the use of fexofenadine in pregnant women. The drug can be used during pregnancy only in case of absolute necessity. The drug is excreted in human milk - not recommended when breastfeeding.
Side effects:
Common: headache, drowsiness, dizziness; nausea, dry mouth. Uncommon: fatigue. After post-marketing experience: hypersensitivity reactions with symptoms such as angioedema, chest tightness, shortness of breath, sudden redness of the skin and generalized symptoms of anaphylaxis; insomnia, nervousness, sleep disturbances or nightmares; tachycardia, arrhythmias; diarrhea; rash, urticaria, pruritus.
Dosage:
Orally. Adults and children from 12 years in seasonal allergic rhinitis: 120 mg once a day; in chronic idiopathic urticaria: 180 mg once a day. No dose adjustment is necessary in elderly patients and patients with impaired liver or kidney function.
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