Prevention of bronchial asthma and symptomatic treatment of allergic rhinitis and allergic conjunctivitis.
Composition:
5 ml syrup contains 1 mg of Ketotifen in the form of ketotifen hydrogen fumarate. The product contains sucrose and sorbitol.
Action:
An antihistaminic drug that binds histamine H receptors1. It inhibits the release of mediators of allergic reactions from mast cells, basophils and from pulmonary tissue. It reduces the hyperresponsiveness of the bronchi, which leads to a decrease in the frequency and weakness of asthmatic attacks. Ketotifen is absorbed from the gastrointestinal tract at 80-90%. Plasma proteins are approximately 75% bound. T0,5 in the blood is 3-5 hours. It is metabolized in the liver and excreted in the urine mainly in the form of inactive metabolites.
Contraindications:
Hypersensitivity to ketotifen or other components of the preparation. Concomitant use of oral antidiabetic agents.
Precautions:
At the beginning of treatment, other anti-asthmatics, especially steroidal preparations (corticosteroids with general action) and adrenocorticotropic hormone should not be stopped due to the possibility of adrenal insufficiency. Caution should be exercised in patients with a history of epilepsy (risk of seizures). The preparation should be discontinued gradually over a period of 2-4 weeks and recur with asthma. Due to the content of sucrose and sorbitol, the preparation should not be used in patients with fructose intolerance, sucrase-isomaltase deficiency or malabsorption of glucose-galactose. The product also contains propyl and methyl parahydroxybenzoate, which may cause allergic reactions (possible late-type reactions).
Pregnancy and lactation:
The preparation can be used during pregnancy only in case of absolute necessity. Due to the penetration of ketotifen into breast milk, women taking ketotifen should not breast-feed.
Side effects:
Common: agitation, irritability, insomnia, nervousness - mainly observed in children. Uncommon: cystitis; dizziness; dryness of the oral mucosa. Rare: weight gain; sedation. Very rare: seizures, hepatitis, increased liver enzymes.
Dosage:
Orally. Children 7 months - 3 years: 0.25 ml (0.05 mg ketotifen) / kg 2 times a day, in the morning and in the evening, during a meal; Do not use more than 2.5 ml 2 times a day. Children over 3 years and adults: 5 ml twice a day, in the morning and in the evening, during a meal. In patients susceptible to sedative effects of Ketotifen, it is recommended to slowly increase the dose for the first week of treatment, starting with 2.5 ml 2 times daily, then increasing to the full therapeutic dose. In the prevention of bronchial asthma, treatment may take several weeks.
(C)
