Symptomatic treatment of allergic rhinitis and chronic idiopathic urticaria.
Composition:
1 capsule contains 10 mg of loratadine; 5 ml of syrup contains 5 mg of loratadine.
Action:
A tricyclic second generation antihistamines blocking peripheral H-receptors1. Poorly penetrates to o.u.n, it has no clinically significant sedative and anticholinergic effects. After oral administration, they are quickly and well absorbed from the gastrointestinal tract. It is extensively metabolised in the first-pass process of the liver, mainly mediated by CYP3A4 and CYP2D6. The main metabolite - desloratadine (DCL) - is pharmacologically active. Maximum concentration of loratadine in the serum occurs after 1-1.5 h and DCL after 1.5-3.7 h. Loratadine is associated with plasma proteins in 97-99% and DCL in 73-76%. Medium T0,5 drug is 8.4 h (3-20 h), the main metabolite - 28 h (8.8-92 h). Loratadine and its metabolites are excreted in urine (approximately 40%) and faeces (approximately 42%).
Contraindications:
Hypersensitivity to loratadine or other ingredients of the preparation. Pregnancy. Children up to 2 years of age
Precautions:
Caution should be exercised in patients with severe hepatic impairment. The preparation in the form of capsules contains sorbitol - it should not be used in patients with rare hereditary fructose intolerance. The syrup formulation contains sucrose - it should not be used in patients with rare inherited disorders associated with fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase deficiency.
Pregnancy and lactation:
Do not use during pregnancy. Use during breastfeeding is not recommended.
Orally. Adults and children over 12 years of age: 10 mg once a day; children 3-12 years old: 5 mg (5 ml of syrup) once a day (less than 30 kg) or 10 mg once a day (above 30 kg). In adults and children about the month of > 30 kg with hepatic failure, treatment starts with a dose of 10 mg every other day, children with ≤ 30 kg 5 mg (5 ml of syrup) every other day. The preparation should be used regardless of meals.
(C)
