the product in the database has an inactive status
indications:
Symptomatic treatment of allergic rhinitis and chronic idiopathic urticaria.
Composition:
1 tabl contains 10 mg of loratadine.
Action:
A tricyclic second generation antihistamines blocking peripheral H-receptors1. It is characterized by a strong action that occurs after 1-3 hours and maintains up to 24 hours. It practically does not penetrate to o.u.n. and does not show affinity for H-receptors1 in o.u.n. It does not have a calming effect, it does not have an anticholinergic effect. loratadine is rapidly absorbed from the digestive tract; the onset of action occurs after about 30 min, and its greatest severity - after 4-6 h. Plasma protein binding is 97%. It is extensively metabolised in the liver to active metabolites. T0,5 in the blood for loratadine it is 3-20 h (average 8.4 hours); for its main active metabolite (decarboethoxyloratadine) - 9-92 h (mean 28 h). Loratadine and its metabolites are excreted in urine (approximately 41%) and faeces (approximately 41%). Administration of the preparation eliminates or reduces the symptoms of allergic rhinitis and conjunctivitis (inhibition of rhinorrhea, sneezing, congestion and edema of the mucous membranes, tears and burning eyes), and also treats skin changes (relief of pruritus).
Contraindications:
Hypersensitivity to loratadine, children up to 3 years old.
Precautions:
Caution is recommended in combination with Itraconazole, ketoconazole, Erythromycin, Clarithromycin, cimetidine, diuretics and other medications that cause potassium loss, despite the lack of clinical effects of these drugs on loratadine.
Pregnancy and lactation:
During pregnancy, use only if the anticipated benefits outweigh the potential risk to the fetus (no adequate, controlled studies in humans). Do not use during breast-feeding.
Side effects:
Headache, fatigue, dry mouth, drowsiness were rarely observed (frequency similar to placebo). Nausea, liver dysfunction, and allergic reactions were extremely rare.
Dosage:
Orally adults and children from 7 years: 10 mg once a day; children 3-6 years old: 5 mg once a day. Patients with hepatic or renal impairment (creatinine clearance less than 30 ml / min) are initially administered 10 mg every other day.
(C)
