The preparation combines the effect of antihistamine with a drug that reduces congestion of the mucous membranes. Pseudoephedrine suppresses the blood vessels of the mucous membrane, and dexbombreniramine maleate exhibits antihistamines. The product reduces swelling of the nasal mucous membrane and clears the nasal passages. It also reduces the discharge of nasal secretion, sneezing and itching of the nose and throat, as well as tearing and itchy eyes occurring in allergic rhinitis. Decsbromfeniramine maleate shows mild sedative effects. Pseudoephedrine sulphate has primarily α-mimetic activity as compared to β-mimetic activity. After oral administration, pseudoephedrine sulfate shrinks the blood vessels and therefore reduces nasal congestion. It exhibits indirect sympathomimetic activity, mainly due to the effect on the release of adrenergic mediators from post-convulsive nerve endings. Pseudoephedrine, when given orally at the recommended doses, can also cause other activities related to stimulation of the sympathetic system, such as increased blood pressure, tachycardia or symptoms of CNS stimulation.
Contraindications:
Hypersensitivity or idiosyncrasy to active substances, other drugs with a similar chemical structure or acting on adrenergic receptors, as well as hypersensitivity to any of the excipients of the preparation. Do not use during treatment with MAO inhibitors and within 2 weeks after its completion and in patients with severe hypertension, severe ischemic heart disease or hyperthyroidism. Do not use during pregnancy and breast-feeding.
Precautions:
Caution should be exercised when using the preparation in patients with narrow-angle glaucoma, peptic ulcer hampering gastrointestinal motility, pyloric duodenal obstruction, prostatic hyperplasia, bladder neck obstruction, cardiovascular disease, as well as patients with elevated intraocular pressure, diabetes mellitus , angina, and patients over 60 years. The efficacy and safety of use in children under 12 years have not been established. The product contains lactose monohydrate 155 mg and sucrose 117 mg, should not be used in patients with rare hereditary galactose intolerance, lactase deficiency (Lapp type) or malabsorption of glucose-galactose, and in patients with rare hereditary disorders associated with fructose intolerance, syndrome poor glucose-galactose absorption or sucrase-isomaltase deficiency. The drug contains butyl parahydroxybenzoate, so it can cause allergic reactions (possible late-type reactions).
Pregnancy and lactation:
Do not use during pregnancy and breast-feeding.
Side effects:
Dexbromfeniramine usually causes light to moderate drowsiness. Other possible side effects: palpitations, tachycardia, arrhythmia, angina pectoris, cardiovascular collapse, tension, tremors, convulsions, dizziness, dizziness, headache, drowsiness, insomnia, dryness of the nose and throat mucosa , breathing problems, dry mouth, nausea, vomiting, increased urine output, impaired urination, urinary bladder spasm or urinary retention, rash, hypersensitivity reactions to sunlight, increased sweating, urticaria, rash, muscle cramps, lack of appetite , hypertension, redness, paleness, chills, weakness, chest pain, anaphylactic shock, anxiety, anxiety, tension.
Dosage:
Orally. Adults and children over 12 years: 1 tabl. 2 times a day (morning and evening). After improvement of 1 tabl. daily is sufficient to effectively control symptoms.
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