the product in the database has an inactive status
indications:
In adults and children aged 6 years and above: alleviation of the symptoms of the nose and eyes associated with seasonal and chronic allergic rhinitis; relieving the symptoms of chronic idiopathic urticaria.
Cetirizine, a metabolite of hydroxyzine, is a potent and selective antagonist of peripheral histamine H-receptors1. In addition, cetirizine has antiallergic activity, inhibits the influx of cells in the late phase of the inflammatory reaction, eosinophils, to the skin and conjunctiva. Cetirizine is well absorbed from the gastrointestinal tract; food prolongs absorption, but does not affect the bioavailability of the drug. It binds approximately 93% to plasma proteins. It is slightly metabolised in the liver and excreted mainly in unchanged form in the urine. T0,5 in the blood is about 10 hours in adults, in children - 5-6 hours.
Contraindications:
Hypersensitivity to cetirizine, hydroxyzine, piperazine derivatives or other components of the preparation. Severe renal impairment (creatinine clearance below 10 ml / min). It must not be used in patients with hereditary galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption.
Precautions:
Caution is recommended in combination with alcohol. Caution is advised when using in patients with epilepsy and in patients at risk of convulsions. It is not recommended to use the preparation in the form of tablets. powl. 10 mg in children under 6 years, because this pharmaceutical form does not allow for a suitable dose adjustment.
Pregnancy and lactation:
Caution should be exercised when using the preparation in pregnant and breast-feeding women, as cetirizine is excreted in human milk.
Side effects:
Drowsiness, fatigue, dizziness, agitation, increased liver enzymes and bilirubin in the blood, rhinitis, pharyngitis, diarrhea, nausea, and abdominal pain have been reported. In isolated cases - difficulty urinating, disturbed eye accommodation, dry mouth. In addition, the following have been reported: thrombocytopenia, anaphylactic shock, hypersensitivity reactions, aggression, confusion, hallucinations, insomnia, tics, convulsions, dysgeusia, dyskinesia, dystonia, paresthesia, syncope, tremor, blurred vision, ocular turnover, tachycardia, angioneurotic edema, pruritus, rash, urticaria, edema, weakness, feeling unwell, weight gain.
Dosage:
Orally. Adults and adolescents over 12 years: 10 mg once a day. In children 6-12 years: 5 mg 2 times a day. In renal insufficiency with a creatinine clearance of 30-49 ml / min 5 mg administered once a day; ≤30 ml / min - 5 mg every 48 h. In children with renal insufficiency, the dose should be determined based on creatinine clearance, age and body weight. The tablets should be taken with water.
(C)
