1 g of cream contains 200 mg of azelaic acid. The preparation contains propylene glycol, cetostearyl alcohol and benzoic acid.
Action:
Azelaic acid has an antibacterial effect, especially on bacteriaPropionibacterium acnesthat affect the development of acne. In addition, it reduces the number of micro-blackheads, as a result of the normalization of the keratin production process and the inhibition of excessive keratinization of the epidermis. The product also has a bleaching effect. Azelaic acid inhibits the activity of tyrosinase and mitochondrial enzymes, thus inhibiting the growth and hyperactivity of melanocytes. After applying the preparation on the skin, it reaches all its layers. researchin vitro showed that the content of azelaic acid after application of a single dose is: in the stratum corneum 3-5%, in the epidermis and dermoid skin up to 10%, in the blood plasma on average 4%. Azelaic acid is 43% bound to plasma proteins. It has a slight β-oxidation. It is mainly excreted in urine in unchanged form. T0,5 after application to the skin is 12 hours.
Contraindications:
Hypersensitivity to azelaic acid and other components of the preparation.
Precautions:
Before starting treatment, the type of discoloration should be determined - Wood's lamp is recommended (the skin form of discoloration is resistant to treatment with the preparation, while the epidermal type and the epidermal-cutaneous skin type are easily treatable). During acne treatment in patients with dark complexion, the skin should be carefully observed due to the whitening action of the preparation. The product contains propylene glycol, which can cause skin irritation, cetostearyl alcohol, which can cause a local skin reaction (eg contact dermatitis) and benzoic acid, which may cause minor irritation of the skin, eyes and mucous membranes. There are insufficient data on the safety and efficacy of treatment with the preparation in children under 12 years of age.
Pregnancy and lactation:
The preparation can be used during pregnancy and breastfeeding only if the anticipated benefits to the mother outweigh the potential risk to the fetus and the fed baby.
Side effects:
Common: signs of local skin irritation such as burning, pruritus, redness, dryness and peeling of the skin (usually occurring at the beginning of treatment, if persist, should be used once a day). In most cases, the symptoms of irritation are mild and usually do not require discontinuation of the preparation. Rare: contact dermatitis, folliculitis, patients with dark complexion - white spots or lightening of the skin at the site of application. Very rare: hypersensitivity reactions to light, allergic skin reactions, eg rash.
Dosage:
Outwardly. Adults and children from 12 years: 1 g cream (4 cm strip) twice a day (in the morning and in the evening) apply a thin layer on washed and thoroughly dried, diseased areas on the skin. Gently rub the cream. Wash your hands thoroughly after applying the product. The daily dose is 2 g of cream (8 cm). Do not take a double dose to make up for a forgotten dose. In the case of acne lesions on the chest and back, do not use more than 10 g of cream per day. Patients with sensitive skin for the first week of treatment should use the product once a day, in the evening. The amount of the applied preparation should be reduced or used once a day in case of significant skin irritation; if necessary, discontinue treatment for a few days. The preparation should be used for at least 4 weeks; for permanent improvement use for several months. Do not use for more than 6 months. Other skin preparations should be applied between successive cream applications.
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